Evidence map›Paper›PMID 32404991›Full record

ArticleThe Journal of antibiotics2020

Diterpenoids isolated from the Samoan marine sponge Chelonaplysilla sp. inhibit Mycobacterium tuberculosis growth.

Josiane A Monteiro de Oliveira, David E Williams, Shilah Bonnett, James Johnson, Tanya Parish, Raymond J Andersen

Abstract read
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In one paragraph

Article in The Journal of antibiotics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Josiane A Monteiro de OliveiraDepartments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2016 Main Mall, Vancouver, BC, V6T 1Z1, Canada.
David E WilliamsDepartments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2016 Main Mall, Vancouver, BC, V6T 1Z1, Canada.
Shilah BonnettTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, 98102, USA.
James JohnsonTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, 98102, USA.
Tanya ParishTB Discovery Research, Infectious Disease Research Institute, Seattle, WA, 98102, USA. tanya.parish@seattlechildrens.org.
Raymond J AndersenDepartments of Chemistry and Earth, Ocean & Atmospheric Sciences, University of British Columbia, 2016 Main Mall, Vancouver, BC, V6T 1Z1, Canada. raymond.andersen@ubc.ca.
Infectious Disease Research Institute · USUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Crude extracts of the marine sponge Chelonaplysilla sp. collected in Samoa, that were obtained from the NCI Open Repository (NCS 21903), inhibited Mycobacterium tuberculosis growth. Assay-guided fractionation of the extract led to the isolation and structural elucidation of the known diterpenoid macfarlandin D (1) and three new diterpenoids macfarlandins F (2), G (3), and H (4). Macfarlandin D (1) exhibited potent antimicrobial activity against M. tuberculosis with an MIC of 1.2 ± 0.4 µg mL

Indexed as

AnimalsAntitubercular AgentsDiterpenesMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMycobacterium tuberculosisPoriferaAntitubercular AgentsDiterpenes

Identifiers

PMID32404991
OpenAlexW3025173632

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.