ArticleScientific reports2020
Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- OCT-guided angle-resolved low-coherence interferometry for microstructural analysis of the human retina.Biomedical optics express · 2026Article
- Comparative Investigation of the Retinal Phenotype of Three Mouse Models of Alzheimer's Disease With Optical Coherence Tomography.Investigative ophthalmology & visual science · 2025Article
- The retinal age gap: an affordable and highly accessible biomarker for population-wide disease screening across the globe.Proceedings. Biological sciences · 2025Article
- Retinal optical coherence tomography intensity spatial correlation features as new biomarkers for confirmed Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Age-Related Retinal Layer Thickness Changes Measured by OCT inInternational journal of molecular sciences · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- OCT Imaging in Murine Models of Alzheimer's Disease in a Systematic Review: Findings, Methodology and Future Perspectives.Biomedicines · 2024Review
- Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Alterations in Retinal Signaling Across Age and Sex in 3xTg Alzheimer's Disease Mice.Journal of Alzheimer's disease : JAD · 2022Article
- Retinal Aging in 3× Tg-AD Mice Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2022Article
- Classification of Transgenic Mice by Retinal Imaging Using SVMS.Computational intelligence and neuroscience · 2022Article
- In vivo multimodal retinal imaging of disease-related pigmentary changes in retinal pigment epithelium.Scientific reports · 2021Article
- Past, present and future role of retinal imaging in neurodegenerative disease.Progress in retinal and eye research · 2021Review
- A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021Article
- Concurrent OCT and OCT angiography of retinal neurovascular degeneration in the 5XFAD Alzheimer's disease mice.Neurophotonics · 2021Article
- Roughness of retinal layers in Alzheimer's disease.Scientific reports · 2021Article
- Article
- Brain and Retinal Abnormalities in the 5xFAD Mouse Model of Alzheimer's Disease at Early Stages.Frontiers in neuroscience · 2021Article
- Spatial scanning of a sample with two-dimensional angle-resolved low-coherence interferometry for analysis of anisotropic scatterers.Biomedical optics express · 2020Article
- Retinal Thickness Changes Over Time in a Murine AD Model APPFrontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
We acquired depth-resolved light scattering measurements from the retinas of triple transgenic Alzheimer's Disease (3xTg-AD) mice and wild type (WT) age-matched controls using co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT). Angle-resolved light scattering measurements were acquired from the nerve fiber layer, outer plexiform layer, and retinal pigmented epithelium using image guidance and segmented thicknesses provided by co-registered OCT B-scans. Analysis of the OCT images showed a statistically significant thinning of the nerve fiber layer in AD mouse retinas compared to WT controls. The a/LCI scattering measurements provided complementary information that distinguishes AD mice by quantitatively characterizing tissue heterogeneity. The AD mouse retinas demonstrated higher mean and variance in nerve fiber layer light scattering intensity compared to WT controls. Further, the difference in tissue heterogeneity was observed through short-range spatial correlations that show greater slopes at all layers of interest for AD mouse retinas compared to WT controls. A greater slope indicates a faster loss of spatial correlation, suggesting a loss of tissue self-similarity characteristic of heterogeneity consistent with AD pathology. Use of this combined modality introduces unique tissue texture characterization to complement development of future AD biomarker analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.