ArticleTranslational psychiatry2020
A neuromarker of individual general fluid intelligence from the white-matter functional connectome.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Mapping the functional connectome between grey matter and white matter.Communications biology · 2026Article
- Developmental changes of the white matter functional connectome.Molecular psychiatry · 2026Article
- Altered Topological Properties of White-Matter Functional Networks in Young Smokers.Addiction biology · 2026Article
- White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder.Psychoradiology · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- Morphological Brain Networks of White Matter: Mapping, Evaluation, Characterization, and Application.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Morphometric brain organization across the human lifespan reveals increased dispersion linked to cognitive performance.PLoS biology · 2024Article
- Altered intersubject functional variability of brain white-matter in major depressive disorder and its association with gene expression profiles.Human brain mapping · 2024Article
- Machine Learning Analysis Classifies Patients with Primary Angle-Closure Glaucoma Using Abnormal Brain White Matter Function.Clinical ophthalmology (Auckland, N.Z.) · 2024Article
- Longitudinal development of the human white matter structural connectome and its association with brain transcriptomic and cellular architecture.Communications biology · 2023Article
- The challenges and prospects of brain-based prediction of behaviour.Nature human behaviour · 2023Review
- Enhancing the network specific individual characteristics in rs-fMRI functional connectivity by dictionary learning.Human brain mapping · 2023Article
- Localized activity alternations in periventricular nodular heterotopia-related epilepsy.CNS neuroscience & therapeutics · 2023Article
- Reduced hippocampal-cortical connectivity during memory suppression predicts the ability to forget unwanted memories.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The relationship between childhood emotional neglect experience and depressive symptoms and prefrontal resting functional connections in college students: The mediating role of reappraisal strategy.Frontiers in behavioral neuroscience · 2023Article
- Mining Correlation between Fluid Intelligence and Whole-brain Large Scale Structural Connectivity.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2023Article
- Driving brain state transitions in major depressive disorder through external stimulation.Human brain mapping · 2022Article
- Shared functional connections within and between cortical networks predict cognitive abilities in adult males and females.Human brain mapping · 2022Article
- The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach.Neural plasticity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuroimaging studies have uncovered the neural roots of individual differences in human general fluid intelligence (Gf). Gf is characterized by the function of specific neural circuits in brain gray-matter; however, the association between Gf and neural function in brain white-matter (WM) remains unclear. Given reliable detection of blood-oxygen-level-dependent functional magnetic resonance imaging (BOLD-fMRI) signals in WM, we used a functional, rather than an anatomical, neuromarker in WM to identify individual Gf. We collected longitudinal BOLD-fMRI data (in total three times, ~11 months between time 1 and time 2, and ~29 months between time 1 and time 3) in normal volunteers at rest, and identified WM functional connectomes that predicted the individual Gf at time 1 (n = 326). From internal validation analyses, we demonstrated that the constructed predictive model at time 1 predicted an individual's Gf from WM functional connectomes at time 2 (time 1 ∩ time 2: n = 105) and further at time 3 (time 1 ∩ time 3: n = 83). From external validation analyses, we demonstrated that the predictive model from time 1 was generalized to unseen individuals from another center (n = 53). From anatomical aspects, WM functional connectivity showing high predictive power predominantly included the superior longitudinal fasciculus system, deep frontal WM, and ventral frontoparietal tracts. These results thus demonstrated that WM functional connectomes offer a novel applicable neuromarker of Gf and supplement the gray-matter connectomes to explore brain-behavior relationships.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.