Evidence map›Paper›PMID 32404858›Full record

ArticleSexually transmitted diseases2020

Sexually Transmitted Infection Prevalence Among Women at Risk for HIV Exposure Initiating Safer Conception Care in Rural, Southwestern Uganda.

Pooja Chitneni, Mwebesa Bosco Bwana, Moran Owembabazi, Kasey O'Neil, Paul Kato Kalyebara, Winnie Muyindike, Nicholas Musinguzi, David R Bangsberg, Jeanne M Marrazzo, Jessica E Haberer and 2 more

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Pooja Chitneni
Mwebesa Bosco Bwana
Moran OwembabaziMassachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.
Kasey O'NeilMassachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.
Paul Kato KalyebaraMbarara Regional Referral Hospital and Mbarara University of Science and Technology, Mbarara, Uganda.
Winnie MuyindikeMbarara Regional Referral Hospital and Mbarara University of Science and Technology, Mbarara, Uganda.
Nicholas MusinguziMassachusetts General Hospital, Mbarara University of Science and Technology Global Health Collaborative, Boston, MA, and Mbarara, Uganda.
David R BangsbergOHSU PSU School of Public Health, Portland, OR.
Jeanne M MarrazzoDivision of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.
Jessica E Haberer
Angela KaidaFaculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.
Lynn T Matthews
Massachusetts General Hospital · USMbarara University of Science and Technology · UGBrigham and Women's Hospital · USUniversity of Alabama at Birmingham · US

Funding

Partnership for Global Health Research Training Program (Renewal)-Supplement for OBSSR, NCI, NCI-AIDS and NIDCDD43TW010543 · FIC · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Wafaie W Fawzi, DAVIDSON HOWES HAMER · 2017 to 2026
$12.1M
PROGRAM FOR AIDS CLINICAL RESEARCH TRAINING (PACRT)T32AI007433 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARK J SIEDNER · 1992 to 2026
$11.4M
Optimizing mHealth for adherence monitoring and interventionK24MH114732 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI HABERER, JESSICA ELIZABETH · 2017 to 2021
$800k
Doris Duke Charitable Foundation 2016094FIC NIH HHS D43 TW010543NIAID NIH HHS T32 AI007433NIMH NIH HHS K24 MH114732
6 · The paper itself

Abstract

backgroundKnowledge of sexually transmitted infection (STI) prevalence and risk factors is important to the development of tenofovir-based preexposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure who were participating in a safer conception study in southwestern Uganda.

methodsWe enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV serostatus (2018-2019). Women were offered comprehensive safer conception counseling, including PrEP. Participants completed interviewer-administered questionnaires detailing sociodemographics and sexual history. We integrated laboratory screening for chlamydia, gonorrhea, trichomoniasis, and syphilis as a substudy to assess STI prevalence. Multivariable logistic regression was used to determine correlates.

resultsNinety-four women completed STI screening (72% of enrolled). Median age was 30 (interquartile range, 26-34) years, and 94% chose PrEP as part of safer conception care. Overall, 24% had STIs: 13% chlamydia, 2% gonorrhea, 6% trichomoniasis, 6% syphilis, and 3% ≥2 STI. Sexually transmitted infection prevalence was associated with younger age (adjusted odds ratio [AOR], 0.87; 95% confidence interval [CI], 0.77-0.99), prior stillbirth (AOR, 5.04; 95% CI, 1.12-22.54), and not feeling vulnerable to HIV (AOR, 16.33; 95% CI, 1.12-237.94).

conclusionsWe describe a 24% curable STI prevalence among women at risk for HIV exposure who were planning for pregnancy. These data highlight the importance of integrating laboratory-based STI screening into safer conception programs to maximize the health of HIV-affected women, children, and families.

Indexed as

GonorrheaHIV InfectionsPre-Exposure ProphylaxisSexually Transmitted DiseasesAdultChildFemaleHumansPregnancyPrevalenceUganda

Identifiers

PMID32404858
PMCPMC7363531
OpenAlexW3026013783

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.