Evidence map›Paper›PMID 32404572›Full record

ArticleJournal of clinical and experimental hematopathology : JCEH2020

A case of hepatosplenic T-cell lymphoma successfully treated by HLA haploidentical stem cell transplantation.

Noriko Iwaki, Kanako Mochizuki, Jun Ozaki, Yoshinobu Maeda, Toshiro Kurokawa

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of clinical and experimental hematopathology : JCEH, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Noriko IwakiDepartment of Hematology, Toyama Red Cross Hospital, Toyama, Japan.
Kanako MochizukiDepartment of Hematology, Toyama Red Cross Hospital, Toyama, Japan.
Jun OzakiDepartment of Hematology, Toyama Red Cross Hospital, Toyama, Japan.
Yoshinobu MaedaDivision of Diagnostic Pathology, Toyama Red Cross Hospital, Toyama, Japan.
Toshiro KurokawaDepartment of Hematology, Toyama Red Cross Hospital, Toyama, Japan.
Toyama University Hospital · JPMatsuyama Red Cross Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of hepatosplenic T-cell lymphoma (HSTL) transplanted from an HLA-haploidentical daughter. A 51-year-old man was referred due to liver function test abnormalities and fever. He was confirmed to have γδ-type HSTL by bone marrow and liver biopsies. He was treated with five cycles of a CHOP regimen. Although metabolic complete response (CR), as defined by positron emission tomography, was achieved, his bone marrow still contained tumor cells on polymerase chain reaction (PCR). He underwent transplantation using unmanipulated peripheral blood stem cells from his HLA-haploidentical daughter. The preconditioning regimen consisted of fludarabine, melphalan, busulfan and antithymocyte globulin. Graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus and short-term methotrexate. Neutrophil engraftment was achieved on day 14. His bone marrow exhibited a completely female phenotype by fluorescence in situ hybridization, and no lymphoma cells were detected by PCR on day 30. Although he developed grade II acute GVHD on day 47, it was successfully treated by prednisolone. He has a limited type of skin chronic GVHD and still receives oral immunosuppressive therapy. He remains in CR four years after transplantation.

Indexed as

Hematopoietic Stem Cell TransplantationTransplantation, HaploidenticalAntineoplastic Combined Chemotherapy ProtocolsCyclophosphamideDoxorubicinGraft vs Host DiseaseHLA AntigensHumansImmunosuppressive AgentsLiver NeoplasmsLymphoma, T-CellMaleMethotrexateMiddle AgedPrednisoloneSplenic NeoplasmsCyclophosphamideDoxorubicinHLA AntigensImmunosuppressive AgentsMethotrexatePrednisoloneTacrolimusVincristinegraft-versus-host disease (GVHD)haploidentical stem cell transplantationhepatosplenic T-cell lymphoma (HSTL)

Identifiers

PMID32404572
PMCPMC7337272
OpenAlexW3025479764

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.