Evidence map›Paper›PMID 32404536›Full record

ArticleAging2020

LncRNA ILF3-AS1 mediated the occurrence of epilepsy through suppressing hippocampal miR-212 expression.

Xiaodong Cai, Ling Long, Chao Zeng, Guanzhong Ni, Yangyang Meng, Qiang Guo, Ziyi Chen, Zhong Li

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
  2. Article
  3. LncRNAs Orchestrating Neuroinflammation: A Comprehensive Review.Cellular and molecular neurobiology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. The regulatory function of lncRNA and constructed network in epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaodong CaiDepartment of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Ling LongDepartment of Neurology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Chao ZengDepartment of Pathology, The Eight Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China.
Guanzhong NiDepartment of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Yangyang MengDepartment of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Qiang GuoDepartment of Neurosurgery, Guangdong 999 Brain Hospital, Guangzhou, China.
Ziyi ChenDepartment of Neurology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Zhong LiDepartment of Neurology, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
Sun Yat-sen University · CNSixth Affiliated Hospital of Sun Yat-sen University · CNGuangdong 999 Brain Hospital · CNThird Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increased expression of some matrix metalloproteinases (MMPs) is closely associated with epilepsy. However, factors that promote their expression have not been clarified. Long noncoding RNAs (lncRNAs) play crucial roles in the development of human diseases, including various cancers, but its potential function in temporal lobe epilepsy (TLE) has remained unexplored. In this study, we showed that hippocampal and serum ILF3-AS1 levels are higher in TLE patients than in matched controls. Interleukin (IL)-1β and tumor necrosis factor (TNF)-α induced ILF3-AS1 expression in astrocytes, while ectopic expression of ILF3-AS1 enhanced IL-6 and TNF-α expression. Ectopic ILF3-AS1 in astrocytes also increased expression of MMP2, MMP3, MMP9 and MMP14, but suppressed expression of miR-212. Consistent with that finding, miR-212 levels were lower in the hippocampus and serum of TLE patients than their controls. This suggests that ILF3-AS1 promotes expression of inflammatory cytokines and MMPs by targeting miR-212 and that ILF3-AS1 plays a crucial role in the development of TLE.

Indexed as

AstrocytesCell Line, TumorCell ProliferationEpilepsyHippocampusHumansMatrix Metalloproteinases, SecretedMicroRNAsNuclear Factor 90 ProteinsRNA, Long NoncodingILF3 protein, humanMatrix Metalloproteinases, SecretedMicroRNAsMIRN212 microRNA, humanNuclear Factor 90 ProteinsRNA, Long NoncodingILF3-AS1long noncoding RNAmiR-212MMPtemporal lobe epilepsy

Identifiers

PMID32404536
PMCPMC7244033
OpenAlexW3025110747

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.