ArticleScience translational medicine2020
Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target.
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Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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80citing papers in PubMed
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Who cites it
80 citing papers in PubMed.
- Innate immune imprints shape HIV-1 reservoir cell persistence during long-term antiretroviral therapy.Nature immunology · 2026Article
- The immunophenotype and proviral landscape of HIV-infected CD4 T cells during antiretroviral therapy.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- HIV-1-encoded circular RNA enhances viral transcription through Tat binding.Nature microbiology · 2026Article
- Clonal dynamics of HIV-infected and uninfected T cells.EBioMedicine · 2026Article
- HIV-seq reveals gene expression differences between HIV-transcribing cells from viremic and suppressed people with HIV.Nature communications · 2026Article
- Single-cell characterization of the gastrointestinal HIV reservoir reveals heterogeneous cellular phenotypes.The Journal of clinical investigation · 2026Article
- Review
- Article
- Tools to Quantify and Characterize the Persistent Reservoir in People with HIV-1: Focus on Non-B Subtypes.Viruses · 2026Review
- Global research landscape and trends of single-cell sequencing in sexually transmitted infections: a comprehensive bibliometric analysis from 2015 to 2025.Frontiers in reproductive health · 2026Article
- Isoforms in action: The impact of transcript diversity in phenotype.Genetics and molecular biology · 2026Article
- Comprehensive Transcriptome Annotation of Thousands of HIV-1 Genomes.bioRxiv : the preprint server for biology · 2025Article
- The STAT Signaling Pathway in HIV-1 Infection: Roles and Dysregulation.International journal of molecular sciences · 2025Review
- Using single cell technologies to understand HIV latency models.Current opinion in HIV and AIDS · 2025Review
- Article
- In vitro HIV DNA integration in STAT3 drives T cell persistence-A model of HIV-associated T cell lymphoma.PLoS pathogens · 2025Article
- Medications for opioid use disorder shape immune responses during chronic HIV infection.Cell reports. Medicine · 2025Article
- HIV Cure: How Far We Have Come?Indian journal of microbiology · 2025Review
- Single-cell analyses identify monocyte gene expression profiles that influence HIV-1 reservoir size in acutely treated cohorts.Nature communications · 2025Article
- EZH2 inhibition mitigates HIV immune evasion, reduces reservoir formation, and promotes skewing of CD8Cell reports · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors.
Runxia LiuDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.ORCID 0000-0002-4145-6042
Yang-Hui Jimmy YehDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.ORCID 0000-0002-7831-9789
Ales VarabyouDepartment of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0003-1060-7212
Jack A ColloraDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.ORCID 0000-0002-6423-2316
Scott Sherrill-MixDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0002-8955-8072
C Conover TalbotInstitute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-3758-2425
Sameet MehtaYale Center for Genome Analysis, Yale University, New Haven, CT 06519, USA.ORCID 0000-0002-3029-3217
Kristen AlbrechtDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA.ORCID 0000-0002-9100-9320
Haiping HaoInstitute for Basic Biomedical Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8826-1568
Hao ZhangDepartment of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Ross A PollackDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Subul A BegDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1862-6012
Rachela M CalviDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Jianfei HuVaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA.
Christine M DurandDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2605-9257
Richard F AmbinderDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-4027-3073
Rebecca HohDepartment of Medicine, University of California, San Francisco, CA 94110, USA.ORCID 0000-0001-5112-4220
Steven G DeeksDepartment of Medicine, University of California, San Francisco, CA 94110, USA.ORCID 0000-0001-6371-747X
Jennifer ChiarellaDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Serena SpudichDepartment of Neurology, Yale University School of Medicine, New Haven, CT 06519, USA.
Daniel C DouekVaccine Research Center, National Institute of Health, Bethesda, MD 20892, USA.
Frederic D BushmanDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.ORCID 0000-0003-4740-4056
Mihaela PerteaDepartment of Computer Science, Whiting School of Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Ya-Chi HoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06519, USA. ya-chi.ho@yale.edu.ORCID 0000-0002-7046-0147
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MUnsolicited R24 for the CFAR-Network of Integrated Clinical Sciences, CNICSR24AI067039 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Michael S. Saag · 2006 to 2026
$99.4MVirology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 1988 to 2026
$93.6MVaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0MViral reservoirs and sanctuaries in HAART - treated patients: role and mechanismsU19AI096109 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, MCCUNE, JOSEPH M · 2011 to 2015
$29.5MFirst-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5MVirus TransmissionP50AI150464 · NIAID · UNIVERSITY OF UTAH · PI SUNDQUIST, WESLEY I. · 2019 to 2021
$14.9MThe HUSH complex in HIV-1 latencyR37AI147868 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI JEREMY LUBAN · 2019 to 2026
$6.4MRole of clonal expansion in HIV-1 persistenceR01AI141009 · NIAID · YALE UNIVERSITY · PI Ya-Chi Ho · 2018 to 2026
$5.3MPredoctoral Training Program in VirologyT32AI055403 · NIAID · YALE UNIVERSITY · PI KUMAR, PRITI, MOTHES, WALTHER H · 2003 to 2024
$3.6MEvaluating the role of opioid medication assisted therapies in HIV-1 Persistence for persons living with HIV and opioid use disordersR61DA047037 · NIDA · YALE UNIVERSITY · PI HO, YA-CHI, KLUGER, YUVAL · 2018 to 2020
$2.3MNCATS NIH HHS UL1 TR001863NCI NIH HHS P30 CA006973NIAID NIH HHS P30 AI027763NIAID NIH HHS P30 AI094189NIAID NIH HHS P50 AI150464NIAID NIH HHS R01 AI141009NIAID NIH HHS R21 AI118402NIAID NIH HHS R24 AI067039NIAID NIH HHS R37 AI147868NIAID NIH HHS T32 AI055403NIAID NIH HHS U19 AI096109NIAID NIH HHS UM1 AI126620NIDA NIH HHS R61 DA047037
Abstract
Understanding HIV-1-host interactions can identify the cellular environment supporting HIV-1 reactivation and mechanisms of clonal expansion. We developed HIV-1 SortSeq to isolate rare HIV-1-infected cells from virally suppressed, HIV-1-infected individuals upon early latency reversal. Single-cell transcriptome analysis of HIV-1 SortSeq
Indexed as
HIV-1HIV InfectionsGene Expression Regulation, ViralHumansTranscription, GeneticVirus ActivationVirus Latency
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.