ArticleThe Journal of biological chemistry2020
The ThiL enzyme is a valid antibacterial target essential for both thiamine biosynthesis and salvage pathways in
Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Synthesis, characterization, X-ray diffraction,RSC advances · 2026Article
- Proteomic Profiling Reveals Intracellular Regulatory Network Disturbance Induced by QseB Deletion inMicroorganisms · 2026Article
- Effects of Different Rearing Systems (Cage vs. Free-Range) on Growth Performance, Serum Biochemical Parameters, Slaughter Performance, Cecal Microbiota, and Hepatic Metabolism of Yellow-Feathered Broilers.Animals : an open access journal from MDPI · 2026Article
- A thiadiazolylidene-morpholine compound inhibits Pseudomonas aeruginosa by destabilizing the thiamine monophosphate kinase thiL.The Journal of biological chemistry · 2026Article
- Nanotherapies based on bacterial metabolism: Mechanisms, design and application.Materials today. Bio · 2025Review
- Chemical genetic interactions elucidate pathways controlling tuberculosis antibiotic efficacy during infection.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Metabolic Reprogramming ofJournal of proteome research · 2024Article
- Combined treatment with vitamin C, hydrocortisone and thiamine does not attenuate morbidity and mortality of septic sheep.Laboratory animal research · 2024Article
- Comparative Genomic and Genetic Evidence on a Role for the OarX Protein in Thiamin Salvage.ACS omega · 2024Article
- Determinants of bacterial survival and proliferation in blood.FEMS microbiology reviews · 2024Review
- Characterization of anBiochemistry · 2024Article
- Antibacterial Components and Modes of the Methanol-Phase Extract fromPlants (Basel, Switzerland) · 2023Article
- The secondary metabolite hydrogen cyanide protectsFrontiers in microbiology · 2023Article
- Examining the genomic features of human and plant-associated Burkholderia strains.Archives of microbiology · 2022Article
- The Involvement of Thiamine Uptake in the Virulence ofPathogens (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thiamine pyrophosphate (TPP) is an essential cofactor for various pivotal cellular processes in all living organisms, including bacteria. Thiamine biosynthesis occurs in bacteria but not in humans; therefore, the enzymes in this pathway are attractive targets for antibiotic development. Among these enzymes, thiamine monophosphate kinase (ThiL) catalyzes the final step of this pathway, phosphorylating thiamine monophosphate to produce TPP. Here, we extensively investigated ThiL in
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