Evidence map›Paper›PMID 32404325›Full record

SynthesisBMJ (Clinical research ed.)2020

Progression to type 2 diabetes in women with a known history of gestational diabetes: systematic review and meta-analysis.

Elpida Vounzoulaki, Kamlesh Khunti, Sophia C Abner, Bee K Tan, Melanie J Davies, Clare L Gillies

2 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 669 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
669citing papers in PubMed, 10 pooled it
52.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06099509 nacompletednot on this mapstarted 2023, after this paper: background citation

Self-Administered 2-Hour Oral Glucose Tolerance Test: A Randomized Controlled Trial

TypeinterventionalSponsorPrisma Health-UpstateRan2023 to 2025Enrolled200ConditionsGestational Diabetes, Postpartum Disorder, Gestational Diabetes Mellitus in PregnancyArmsSelf-administered oral glucose tolerance test
NCT06355154 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Moderate Carbohydrate Consumption on Metabolic and Obstetric Outcomes in Pregnant Women With Insulin-treated Diabetes- A Randomized Controlled Trial

TypeinterventionalSponsorHadassah Medical OrganizationRan2024 to 2028Enrolled120ConditionsDiabetes in PregnancyArmsNutritional intervention
3 · Its place in the literature

Who cites it

669 citing papers in PubMed, 10 syntheses or guidelines pooled it, 1,051 citations in OpenAlex.

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609 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Elpida VounzoulakiDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK ev63@le.ac.uk.ORCID http://orcid.org/0000-0003-3137-8295
Kamlesh KhuntiDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
Sophia C AbnerDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
Bee K TanDepartment of Cardiovascular Sciences, University of Leicester, Leicester, UK.
Melanie J DaviesDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
Clare L GilliesDiabetes Research Centre, Leicester General Hospital, University of Leicester, Leicester, UK.
University of Leicester · GB

Funding

Medical Research Council MR/P013538/1Medical Research Council MR/P013538/2Medical Research Council MR/R020981/1Medical Research Council MR/R020981/2
6 · The paper itself

Abstract

objectiveTo estimate and compare progression rates to type 2 diabetes mellitus (T2DM) in women with gestational diabetes mellitus (GDM) and healthy controls.

designSystematic review and meta-analysis. DATA SOURCES: Medline and Embase between January 2000 and December 2019, studies published in English and conducted on humans. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Observational studies investigating progression to T2DM. Inclusion criteria were postpartum follow-up for at least 12 months, incident physician based diagnosis of diabetes, T2DM reported as a separate outcome rather than combined with impaired fasting glucose or impaired glucose tolerance, and studies with both a group of patients with GDM and a control group.

resultsThis meta-analysis of 20 studies assessed a total of 1 332 373 individuals (67 956 women with GDM and 1 264 417 controls). Data were pooled by random effects meta-analysis models, and heterogeneity was assessed by use of the I

conclusionsWomen with a history of GDM appear to have a nearly 10-fold higher risk of developing T2DM than those with a normoglycaemic pregnancy. The magnitude of this risk highlights the importance of intervening to prevent the onset of T2DM, particularly in the early years after pregnancy. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42019123079.

Indexed as

Diabetes, GestationalDiabetes Mellitus, Type 2Disease ProgressionFemaleHumansIncidencePostpartum PeriodPregnancyRisk Factors

Identifiers

PMID32404325
PMCPMC7218708
OpenAlexW3016572394

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.