Evidence map›Paper›PMID 32404135›Full record

ArticleBMC research notes2020

Microarray analysis of formalin-fixed, paraffin-embedded follicular thyroid carcinoma samples from patients who developed postoperative distant metastasis.

Tomoo Jikuzono, Tomoko Ishikawa, Mitsuyoshi Hirokawa, Iwao Sugitani, Osamu Ishibashi

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tomoo JikuzonoLaboratory of Biological Macromolecules, Department of Applied Life Sciences, Graduate School of Life & Environmental Sciences, Osaka Prefecture University, 1‑1 Gakuen‑cho, Sakai, 599‑8531, Japan.
Tomoko IshikawaInstitute for Human Life Innovation, Ochanomizu University, 2‑1‑1 Otsuka, Bunkyo‑ku, Tokyo, 112‑8610, Japan.
Mitsuyoshi HirokawaDepartment of Diagnostic Pathology and Cytology, Kuma Hospital, 8‑2‑35 Shimoyamate‑dori, Chuo‑ku, Kobe, 650‑0011, Japan.
Iwao SugitaniDepartment of Endocrine Surgery, Nippon Medical School, 1‑1‑5 Sendagi, Bunkyo‑ku, Tokyo, 113‑8602, Japan.
Osamu IshibashiLaboratory of Biological Macromolecules, Department of Applied Life Sciences, Graduate School of Life & Environmental Sciences, Osaka Prefecture University, 1‑1 Gakuen‑cho, Sakai, 599‑8531, Japan. ishibashi@biochem.osakafu-u.ac.jp.ORCID http://orcid.org/0000-0003-4698-460X

Funding

Japan Society for the Promotion of Science Kakenhi 15K10063Japan Society for the Promotion of Science Kakenhi 19K05954Japan Society for the Promotion of Science Kakenhi 19K09055
6 · The paper itself

Abstract

objectiveAlthough follicular thyroid carcinoma (FTC) generally has a good prognosis, it occasionally metastasises, leading to poor prognosis. Unfortunately, minimally invasive FTC (mi-FTC) and encapsulated angioinvasive FTC (ea-FTC) cannot be distinguished cytopathologically from thyroid follicular adenoma (FTA), a benign tumour with a good prognosis. Therefore, a molecular diagnosis to distinguish mi- or ea-FTC from FTA is needed for clinical treatment. Several transcriptomics/proteomics studies have searched for FTC biomarkers. However, the results of these studies were not consistent, which could be partly explained by inaccurate diagnosis of the specimens analysed. DATA DESCRIPTION: We conducted a microarray-based genome-wide transcriptome analysis using formalin-fixed paraffin-embedded mi- or ea-FTC specimens from patients who developed distant metastasis up to 10 years postoperatively, which ensured the accuracy of diagnosis.

Indexed as

Gene Expression ProfilingAdenocarcinoma, FollicularFollow-Up StudiesFormaldehydeHumansMicroarray AnalysisNeoplasm MetastasisParaffin EmbeddingThyroid NeoplasmsFormaldehydeEncapsulated angioinvasive follicular thyroid carcinomaFormalin-fixed and paraffin-embedded samplesMicroarray analysisMinimally invasive follicular thyroid carcinoma

Identifiers

PMID32404135
PMCPMC7218651

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.