ArticleBMC psychiatry2020
Risk and risk factors for disability pension among patients with treatment resistant depression- a matched cohort study.
Article in BMC psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Review
- Psychiatric outcomes and long-term school and work-related disability in offspring of parents with depression and treatment-resistant depression.Social psychiatry and psychiatric epidemiology · 2026Article
- Impact analysis of expanded access to ketamine for treatment-resistant depression.Journal of comparative effectiveness research · 2025Article
- Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder.BMC psychiatry · 2025Article
- Implementation of a ketamine programme for treatment-resistant depression in the public health system: Lessons from the first Australian public hospital clinic.The Australian and New Zealand journal of psychiatry · 2024Article
- Association between blood cadmium and depression varies by age and smoking status in US adult women: a cross-sectional study from NHANES 2005-2016.Environmental health and preventive medicine · 2024Article
- Association of Treatment-Resistant Depression With Patient Outcomes and Health Care Resource Utilization in a Population-Wide Study.JAMA psychiatry · 2023Observational
- Healthcare utilization, costs, and productivity losses in treatment-resistant depression in Finland - a matched cohort study.BMC psychiatry · 2022Article
- Treatment-resistant depression and labor market affiliation in the Danish welfare society: a register-based study.Social psychiatry and psychiatric epidemiology · 2022Article
- Laterality and Sex Differences of Human Lateral Habenula Afferent and Efferent Fiber Tracts.Frontiers in neuroscience · 2022Article
- Using machine learning to investigate earning capacity in patients undergoing psychosomatic rehabilitation-A retrospective health data analysis.Frontiers in psychiatry · 2022Article
- Deep Brain Stimulation Is Effective for Treatment-Resistant Depression: A Meta-Analysis and Meta-Regression.Journal of clinical medicine · 2020Article
- Article
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundTreatment resistant depression (TRD) is common among patients with depression, and is associated with clinical and functional disability. However, the risk and risk factors for being granted disability pension (DP) among patients with TRD have not been investigated.
methodsAll antidepressant initiators in Sweden with a diagnosis of depression in specialized care were identified in nationwide registers 2006-2013 and followed regarding treatment trials. TRD was defined as the start of a third sequential trial. Patients with TRD who were not on DP (N = 3204) were matched by age, sex, history of depression, calendar year, and time for treatment start with 3204 comparators with depression and ongoing antidepressant treatment. A proportional Cox Regression was performed with DP as outcome, adjusted for various sociodemographic and clinical covariates.
resultsCompared to the comparison cohort, TRD was associated with a doubled risk for all-cause DP (aHR 2.07; 95%CI 1.83-2.35), DP due to depression (2.28; 1.82-2.85) and to any mental disorder (2.24; 1.95-2.57) but not due to somatic diagnoses (1.25; 0.84-1.86). Among significant risk factors for DP in TRD were female sex, being > 29 years of age, unemployment and a diagnosis of comorbid personality disorder (ICD-10 codes F60.0-9).
conclusionTRD is associated with an elevated risk for DP compared to other patients with depression, with large potential costs for the affected patients and for society. Clinical and therapeutic implications for patients with TRD who are granted DP should be further investigated. LIMITATION: No clinical data, e.g. type of depression or reason for treatment switch, was available for this study.
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