Evidence map›Paper›PMID 32404052›Full record

ArticleBMC neuroscience2020

Resuscitation with macromolecular superoxide dismutase/catalase mimetic polynitroxylated PEGylated hemoglobin offers neuroprotection in guinea pigs after traumatic brain injury combined with hemorrhage shock.

Soichiro Seno, Jun Wang, Suyi Cao, Manda Saraswati, Sharon Park, Jan Simoni, Li Ma, Bohdan Soltys, Carleton J C Hsia, Raymond C Koehler and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
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  5. Article
  6. Fluids of the Future.Frontiers in veterinary science · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Soichiro SenoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Jun WangDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Suyi CaoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Manda SaraswatiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Sharon ParkDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Jan SimoniAntiRadical Therapeutics, Sioux Falls, SD, USA.
Li MaDepartment of Physics, Georgia Southern University, Statesboro, GA, USA.
Bohdan SoltysAntiRadical Therapeutics, Sioux Falls, SD, USA.
Carleton J C HsiaAntiRadical Therapeutics, Sioux Falls, SD, USA.
Raymond C KoehlerDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA. rkoehler@jhmi.edu.ORCID 0000-0002-5890-9992
Courtney L RobertsonDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University, 600 North Wolfe Street, Blalock 1404, Baltimore, MD, USA.
Johns Hopkins University · USAntimicrobial Materials (United States) · USGeorgia Southern University · US

Funding

Medical Research and Materiel Command W81XWH-17-C-0223
6 · The paper itself

Abstract

backgroundPolynitroxylated PEGylated hemoglobin (PNPH, aka SanFlow) possesses superoxide dismutase/catalase mimetic activities that may directly protect the brain from oxidative stress. Stabilization of PNPH with bound carbon monoxide prevents methemoglobin formation during storage and permits it to serve as a carbon monoxide donor. We determined whether small volume transfusion of hyperoncotic PNPH is neuroprotective in a polytrauma model of traumatic brain injury (TBI) plus hemorrhagic shock. Guinea pigs were used because, like humans, they do not synthesize their own ascorbic acid, which is important in reducing methemoglobin.

resultsTBI was produced by controlled cortical impact and was followed by 20 mL/kg hemorrhage to a mean arterial pressure (MAP) of 40 mmHg. At 90 min, animals were resuscitated with 20 mL/kg lactated Ringer's solution or 10 mL/kg PNPH. Resuscitation with PNPH significantly augmented the early recovery of MAP after hemorrhagic shock by 10-18 mmHg; whole blood methemoglobin was only 1% higher and carboxyhemoglobin was 2% higher. At 9 days of recovery, unbiased stereology analysis revealed that, compared to animals resuscitated with lactated Ringer's solution, those treated with PNPH had significantly more viable neurons in the hippocampus CA1 + 2 region (59 ± 10% versus 87 ± 18% of sham and naïve mean value) and in the dentate gyrus (70 ± 21% versus 96 ± 24%; n = 12 per group).

conclusionPNPH may serve as a small-volume resuscitation fluid for polytrauma involving TBI and hemorrhagic shock. The neuroprotection afforded by PNPH seen in other species was sustained in a species without endogenous ascorbic acid synthesis, thereby supporting potential translatability for human use.

Indexed as

ResuscitationAnimalsBrain Injuries, TraumaticCatalaseGuinea PigsHemorrhageNeuroprotectionNeuroprotective AgentsShock, HemorrhagicCatalaseNeuroprotective AgentsCarbon monoxideControlled cortical impactGuinea pigHemoglobin-based oxygen carrierHippocampusNeuroprotection

Identifiers

PMID32404052
PMCPMC7222507
OpenAlexW3026479486

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.