Evidence map›Paper›PMID 32403927›Full record

ArticleACS sensors2020

N-Terminal Derivatization-Assisted Identification of Individual Amino Acids Using a Biological Nanopore Sensor.

Xiaojun Wei, Dumei Ma, Zehui Zhang, Leon Y Wang, Jonathan L Gray, Libo Zhang, Tianyu Zhu, Xiaoqin Wang, Brian J Lenhart, Yingwu Yin and 2 more

Abstract read
In one paragraph

Article in ACS sensors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. RSC advances · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Nanopore Detection Assisted DNA Information Processing.Nanomaterials (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
  12. Review
  13. Sensors and actuators. B, Chemical · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaojun WeiBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.
Dumei MaDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Zehui ZhangBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.
Leon Y WangDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
Jonathan L GrayBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.
Libo ZhangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Tianyu ZhuDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0001-9115-6462
Xiaoqin WangDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
Brian J LenhartDepartment of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
Yingwu YinDepartment of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005 Fujian, China.ORCID 0000-0002-9123-7761
Qian WangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0002-2149-384X
Chang LiuBiomedical Engineering Program, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0001-8097-9631

Funding

Supplement for South Carolina BRIN - 1P20 RR16461P20RR016461 · NCRR · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI PIRISI-CREEK, LUCIA AMELIA · 2001 to 2011
$32.3M
A Solid-State Nanopore Biosensor for Rapid Detection of Mycobacterium tuberculosis Antigens in Pediatric Blood SamplesK22AI136686 · NIAID · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LIU, CHANG · 2019 to 2020
$265k
NCRR NIH HHS P20 RR016461NIAID NIH HHS K22 AI136686
6 · The paper itself

Abstract

Nanopore technology has been employed as a powerful tool for DNA sequencing and analysis. To extend this method to peptide sequencing, a necessary step is to profile individual amino acids (AAs) through their nanopore stochastic signals, which remains a great challenge because of the low signal-to-noise ratio and unpredictable conformational changes of AAs during their translocation through nanopores. We showed that the combination of an N-terminal derivatization strategy of AAs with nanopore technology could lead to effective

Indexed as

NanoporesAmino AcidsAmino Acid SequenceHemolysin ProteinsPeptidesAmino AcidsHemolysin ProteinsPeptidesamino acidderivatizationidentificationnanoporeproteomics

Identifiers

PMID32403927
PMCPMC7978492

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.