ArticleOptics express2020
Background-free imaging of chemical bonds by a simple and robust frequency-modulated stimulated Raman scattering microscopy.
Article in Optics express, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Multimodal Optical Imaging Platform for Studying Cellular Metabolism.Journal of visualized experiments : JoVE · 2025Article
- Imaging Metabolic Flow of Water in Plants with Isotope-Traced Stimulated Raman Scattering Microscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Fast Real-Time Brain Tumor Detection Based on Stimulated Raman Histology and Self-Supervised Deep Learning Model.Journal of imaging informatics in medicine · 2024Article
- Spectral focusing-based stimulated Raman scattering microscopy using compact glass blocks for adjustable dispersion.Biomedical optics express · 2023Article
- Frequency modulation stimulated Raman scattering scheme for real-time background correction with a single light source.Biomedical optics express · 2023Article
- Physics and applications of Raman distributed optical fiber sensing.Light, science & applications · 2022Review
- Spectral focusing in picosecond pulsed stimulated Raman scattering microscopy.Biomedical optics express · 2022Article
- Label-free skin penetration analysis using time-resolved, phase-modulated stimulated Raman scattering microscopy.Biomedical optics express · 2021Article
- Super-resolution vibrational microscopy by stimulated Raman excited fluorescence.Light, science & applications · 2021Article
- Advances in stimulated Raman scattering imaging for tissues and animals.Quantitative imaging in medicine and surgery · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Being able to image chemical bonds with high sensitivity and speed, stimulated Raman scattering (SRS) microscopy has made a major impact in biomedical optics. However, it is well known that the standard SRS microscopy suffers from various backgrounds, limiting the achievable contrast, quantification and sensitivity. While many frequency-modulation (FM) SRS schemes have been demonstrated to retrieve the sharp vibrational contrast, they often require customized laser systems and/or complicated laser pulse shaping or introduce additional noise, thereby hindering wide adoption. Herein we report a simple but robust strategy for FM-SRS microscopy based on a popular commercial laser system and regular optics. Harnessing self-phase modulation induced self-balanced spectral splitting of picosecond Stokes beam propagating in standard single-mode silica fibers, a high-performance FM-SRS system is constructed without introducing any additional signal noise. Our strategy enables adaptive spectral resolution for background-free SRS imaging of Raman modes with different linewidths. The generality of our method is demonstrated on a variety of Raman modes with effective suppressing of backgrounds including non-resonant cross phase modulation and electronic background from two-photon absorption or pump-probe process. As such, our method is promising to be adopted by the SRS microscopy community for background-free chemical imaging.
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Registered trials
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