Evidence map›Paper›PMID 32403403›Full record

ReviewJournal of clinical medicine2020

MSI and EBV Positive Gastric Cancer's Subgroups and Their Link With Novel Immunotherapy.

Maria Grazia Rodriquenz, Giandomenico Roviello, Alberto D'Angelo, Daniele Lavacchi, Franco Roviello, Karol Polom

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Estimating the global burden of Epstein-Barr virus-related cancers.Journal of cancer research and clinical oncology · 2022
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Immune checkpoint inhibition inFrontiers in oncology · 2026
    Article
  7. Article
  8. The role and application prospects of ANXA1 in gastric cancer cells.Medical oncology (Northwood, London, England) · 2025
    Review
  9. Article
  10. Review
  11. Therapeutic opportunities in EBV-positive gastric cancer subtypes.Therapeutic advances in medical oncology · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Cancers · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 3 countries.

Maria Grazia RodriquenzDivision of Medical Oncology, Department of Onco-Hematology, IRCCS-CROB, Referral Cancer Center of Basilicata, via Padre Pio 1, 85028 Rionero, Vulture (PZ), Italy.
Giandomenico RovielloDepartment of Health Sciences, University of Florence, viale Pieraccini, 6, 50139 Florence, Italy.
Alberto D'AngeloDepartment of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK.
Daniele LavacchiAzienda Ospedaliera Careggi University Hospital of Florence and University of Florence, 50134 Florence, Italy.
Franco RovielloDepartment of Medical, Surgical and Neuro Sciences, Section of Surgery, Azienda Ospedaliera Universitaria Senese, University of Siena, 53100 Siena, Italy.
Karol PolomDepartment of Surgical Oncology, Gdansk Medical University, 80-210 Gdansk, Poland.
Azienda Ospedaliero-Universitaria Careggi · ITCentro di Riferimento Oncologico della Basilicata · ITGdańsk Medical University · PLUniversity of Bath · GBUniversity of Florence · ITUniversity of Siena · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancers have been historically classified based on histomorphologic features. The Cancer Genome Atlas network reported the comprehensive identification of genetic alterations associated with gastric cancer, identifying four distinct subtypes- Epstein-Barr virus (EBV)-positive, microsatellite-unstable/instability (MSI), genomically stable and chromosomal instability. In particular, EBV-positive and MSI gastric cancers seem responsive to novel immunotherapies drugs. The aim of this review is to describe MSI and EBV positive gastric cancer's subgroups and their relationship with novel immunotherapy.

Indexed as

EBVimmunotherapymolecular subtypesMSI

Identifiers

PMID32403403
PMCPMC7291039
OpenAlexW3022265620

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.