Evidence map›Paper›PMID 32403373›Full record

ArticleJournal of clinical medicine2020

Association between Very Low-Density Lipoprotein Cholesterol (VLDL-C) and Carotid Intima-Media Thickness in Postmenopausal Women Without Overt Cardiovascular Disease and on LDL-C Target Levels.

Marco Gentile, Arcangelo Iannuzzi, Francesco Giallauria, Antonello D'Andrea, Elio Venturini, Mario Pacileo, Giuseppe Covetti, Camilla Panico, Amalia Mattiello, Giuseppe Vitale and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Very low-density lipoprotein and the human health.World journal of experimental medicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 1 country.

Marco GentileDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.ORCID 0000-0003-3744-6375
Arcangelo IannuzziDepartment of Medicine and Medical Specialties, "Antonio Cardarelli" Hospital, 80131 Naples, Italy.
Francesco Giallauria"Federico II" University of Naples, Department of Translational Medical Sciences, 80131 Naples, Italy.ORCID 0000-0003-4119-9397
Antonello D'AndreaCardiology and Intensive Care Units, "Umberto I" Hospital, Viale San Francesco, 84014 Nocera Inferiore (Salerno), Italy.ORCID 0000-0002-9698-9145
Elio VenturiniCardiac Rehabilitation Unit, Azienda USL Toscana Nord-Ovest, Cecina Civil Hospital, 57023 Cecina (LI), Italy.
Mario PacileoCardiology and Intensive Care Units, "Umberto I" Hospital, Viale San Francesco, 84014 Nocera Inferiore (Salerno), Italy.
Giuseppe CovettiDepartment of Medicine and Medical Specialties, "Antonio Cardarelli" Hospital, 80131 Naples, Italy.
Camilla PanicoDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.
Amalia MattielloDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.
Giuseppe VitaleCardiovascular Rehabilitation Unit, "Buccheri La Ferla Fatebenefratelli" Hospital, 90123 Palermo, Italy.ORCID 0000-0002-1565-6550
Filippo Maria SarulloCardiovascular Rehabilitation Unit, "Buccheri La Ferla Fatebenefratelli" Hospital, 90123 Palermo, Italy.
Paolo RubbaDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.
Carlo Vigorito"Federico II" University of Naples, Department of Translational Medical Sciences, 80131 Naples, Italy.
Salvatore PanicoDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.
Gabriella IannuzzoDepartment of Clinical Medicine and Surgery, "Federico II" University, 80131 Naples, Italy.
Federico II University Hospital · ITFatebenefratelli Hospital · ITOspedale Antonio Cardarelli · ITPoliclinico Umberto I · ITAzienda Usl Toscana Centro · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundatherosclerotic process inexorably advances in patients reaching low-density lipoprotein cholesterol (LDL-C) targets. An attractive hypothesis is that lipoprotein particles (very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL)), could contribute to residual risk. The present study aims to investigate the relationship between carotid intima-media thickness (IMT) and different lipoprotein subfractions in a cohort of healthy postmenopausal women.

methods75 postmenopausal women, at LDL-C target levels without overt cardiovascular disease, underwent biochemical analyses (including subfraction assay of plasma lipoproteins) and carotid ultrasound examination.

resultsa statistically significant correlation between VLDL and carotid IMT (

conclusionsin this cohort of postmenopausal women, VLDL-C was significantly associated to carotid IMT, independent of main cardiovascular risk factors. These findings pave the way for targeting circulating concentrations of VLDL-C to reduce cardiovascular events in patients with target LDL-C levels.

Indexed as

atherosclerosiscarotid intima-media thicknessmenopauseVLDLwomen

Identifiers

PMID32403373
PMCPMC7290892
OpenAlexW3021628257

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.