Evidence map›Paper›PMID 32403274›Full record

ArticlePharmaceuticals (Basel, Switzerland)2020

Is the Way to Fight Cancer Paved with Gold? Metal-Based Carbene Complexes with Multiple and Fascinating Biological Features.

Domenico Iacopetta, Camillo Rosano, Marco Sirignano, Annaluisa Mariconda, Jessica Ceramella, Marco Ponassi, Carmela Saturnino, Maria Stefania Sinicropi, Pasquale Longo

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Synthesis of (1,10-Phenanthroline-Molecules (Basel, Switzerland) · 2025
    Article
  10. AuInternational journal of molecular sciences · 2025
    Article
  11. Article
  12. Review
  13. NHC-Ag(I) and NHC-Au(I) Complexes withACS medicinal chemistry letters · 2023
    Article
  14. Exploring the Potential of Metal-Based Candidate Drugs as Modulators of the Cytoskeleton.Chembiochem : a European journal of chemical biology · 2023
    Review
  15. Indolo[2,3-Dalton transactions (Cambridge, England : 2003) · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Synthesis of NovelAntibiotics (Basel, Switzerland) · 2023
    Article
  20. 5,8-Dimethyl-9Pharmaceuticals (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Domenico IacopettaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0001-5179-7118
Camillo RosanoBiopolymers and Proteomics IRCCS, Ospedale Policlinico San Martino-IST, Largo R. Benzi 10, 16132 Genova, Italy.
Marco SirignanoDepartment of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
Annaluisa MaricondaDepartment of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.
Jessica CeramellaDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.
Marco PonassiBiopolymers and Proteomics IRCCS, Ospedale Policlinico San Martino-IST, Largo R. Benzi 10, 16132 Genova, Italy.
Carmela SaturninoDepartment of Science, University of Basilicata, Viale dell'Ateneo Lucano 10, 85100 Potenza, Italy.ORCID 0000-0002-7419-8780
Maria Stefania SinicropiDepartment of Pharmacy, Health and Nutritional Sciences, University of Calabria, Via P. Bucci, 87036 Arcavacata di Rende, Italy.ORCID 0000-0003-2435-8931
Pasquale LongoDepartment of Biology and Chemistry, University of Salerno, Via Giovanni Paolo II, 132, 84084 Fisciano, Italy.
University of Calabria · ITOspedale Policlinico San Martino · ITUniversity of Basilicata · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report the synthesis and the multiple anti-tumor properties of new gold and silver carbene complexes. The chemical modifications, grounded on our previous studies, led us to identify a good lead complex, gold-based, whose biological features are very exciting and promising in the anti-cancer research and could be further developed. Indeed, the bis-[4,5-dichloro-(

Indexed as

carbene complexesdocking studieshuman topoisomerases I and IItubulinwomen cancers

Identifiers

PMID32403274
PMCPMC7281280
OpenAlexW3023222022

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.