Evidence map›Paper›PMID 32403251›Full record

ArticleAntioxidants (Basel, Switzerland)2020

The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury.

Francesca V LoBianco, Kimberly J Krager, Gwendolyn S Carter, Sinthia Alam, Youzhong Yuan, Elise G Lavoie, Jonathan A Dranoff, Nukhet Aykin-Burns

Open access · goldAbstract read
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Radiation-induced liver disease: beyond DNA damage.Cell cycle (Georgetown, Tex.) · 2023
    Review
  7. ALKBH5-mediated mClinical and translational medicine · 2023
    Article
  8. The sirtuin family in health and disease.Signal transduction and targeted therapy · 2022
    Review
  9. Article
  10. Article
  11. Review
  12. Sirtuins at the Service of Healthy Longevity.Frontiers in physiology · 2021
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Francesca V LoBiancoDivision of Radiation Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.ORCID 0000-0002-2285-3878
Kimberly J KragerDivision of Radiation Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Gwendolyn S CarterDivision of Radiation Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Sinthia AlamDivision of Radiation Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Youzhong YuanDepartment of Pathology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Elise G LavoieDepartment of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Jonathan A DranoffDepartment of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.
Nukhet Aykin-BurnsDivision of Radiation Health, University of Arkansas for Medical Sciences, 4301 W. Markham St., Little Rock, AR 72205, USA.ORCID 0000-0001-8574-4102
University of Arkansas for Medical Sciences · US

Funding

The Role o f Tetrahydrobiopterin (BH4) Bioavailability in Radiation-induced Skin InjuryP20GM109005 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI WOLFE, TATIANA · 2015 to 2024
$21.1M
Systems Pharmacology and Toxicology Training ProgramT32GM106999 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2013 to 2022
$1.4M
Arkansas Science and Technology Authority Award AWD50506 15-B-19NIGMS NIH HHS P20 GM109005NIGMS NIH HHS T32 GM106999
6 · The paper itself

Abstract

In patients with abdominal region cancers, ionizing radiation (IR)-induced long-term liver injury is a major limiting factor in the use of radiotherapy. Previously, the major mitochondrial deacetylase, sirtuin 3 (SIRT3), has been implicated to play an important role in the development of acute liver injury after total body irradiation but no studies to date have examined the role of SIRT3 in liver's chronic response to radiation. In the current study, ten-month-old Sirt3

Indexed as

hydroperoxideinflammationionizing radiationliversirtuin 3

Identifiers

PMID32403251
PMCPMC7278565
OpenAlexW3023943305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.