ReviewParasite immunology2020
A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.
Review in Parasite immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Tissue-Specific Transcriptomic Insights into Myxozoan Infections: Immune and Stress Responses in the Kidney and Head Cartilage of Rainbow Trout.International journal of molecular sciences · 2026Article
- Integrated Physiological and Transcriptomic Analyses Suggest Key Adaptive Mechanisms of European Perch (Animals : an open access journal from MDPI · 2026Article
- Review of Major and Minor Pathogens of Adult Pacific Salmon (Pathogens (Basel, Switzerland) · 2026Review
- Size-dependent heavy metal and parasite bioaccumulation in Mugil cephalus from lake manzala: human health risks and fish histopathological lesions.Scientific reports · 2025Article
- Transcriptomic Analysis of the Rainbow Trout Response to Single and Co-Infections withInternational journal of molecular sciences · 2025Article
- Protective immune response in rainbow trout (Frontiers in immunology · 2025Article
- Parental influence on brown trout offspring immune cell composition: An infection study with Tetracapsuloides bryosalmonae.PloS one · 2025Article
- Genome-wide characterization and comparative expression profiling ofFrontiers in immunology · 2024Article
- The myxozoansFrontiers in cellular and infection microbiology · 2024Article
- The Immune Response to the Myxozoan ParasiteInternational journal of molecular sciences · 2023Review
- Red mark syndrome: Is the aquaculture water microbiome a keystone for understanding the disease aetiology?Frontiers in microbiology · 2023Article
- Red blood cells in proliferative kidney disease-rainbow trout (Frontiers in immunology · 2023Article
- It's a hard knock life for some: Heterogeneity in infection life history of salmonids influences parasite disease outcomes.The Journal of animal ecology · 2021Article
- A portrait of the immune response to proliferative kidney disease (PKD) in rainbow trout.Parasite immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Proliferative kidney disease (PKD), caused by the myxozoan Tetracapsuloides bryosalmonae, is one of the most serious parasitic diseases of salmonids in which outbreaks cause severe economic constraints for the aquaculture industry and declines of wild species throughout Europe and North America. Given that rainbow trout (Oncorhynchus mykiss) is one of the most widely farmed freshwater fish and an important model species for fish immunology, most of the knowledge on how the fish immune response is affected during PKD is from this organism. Once rainbow trout are infected, PKD pathogenesis results in a chronic kidney immunopathology mediated by decreasing myeloid cells and increasing lymphocytes. Transcriptional studies have revealed the regulation of essential genes related to T-helper (Th)-like functions and a dysregulated B-cell antibody type response. Recent reports have discovered unique details of teleost B-cell differentiation and functionality and characterized the differential immunoglobulin (Ig)-mediated response. These studies have solidified the rainbow trout T. bryosalmonae system as a sophisticated disease model capable of feeding key advances into mainstream immunology and have contributed essential information to design novel parasite disease prevention strategies. In our following perspective, we summarize these efforts to evaluate the immune mechanisms of rainbow trout during PKD pathogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.