Evidence map›Paper›PMID 32403117›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2020

Glutamatergic hypo-function in the left superior and middle temporal gyri in early schizophrenia: a data-driven three-dimensional proton spectroscopic imaging study.

Juan R Bustillo, Joel Upston, Elizabeth Grace Mayer, Thomas Jones, Andrew A Maudsley, Charles Gasparovic, Mauricio Tohen, Rhoshel Lenroot

Registry-linked trialOpen access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05890768 (The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05890768 phase4withdrawnnot on this mapstarted 2023, after this paper: background citation

The Relationship Between the Efficacy of Lumateperone and Central Glutamate and Dopaminergic Metabolism: A Comparison With Risperidone in First Episode Psychosis

TypeinterventionalSponsorUniversity of New MexicoRan2023 to 2024Enrolled0ConditionsPsychosisArmsLumateperone, Risperidone
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Synaptic dysfunction and adaptation after NMDA receptor ablation in the mouse medial prefrontal cortex.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  3. Article
  4. Article
  5. Higher striatal glutamate in male youth with internet gaming disorder.European archives of psychiatry and clinical neuroscience · 2024
    Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Juan R BustilloDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA. jbustillo@salud.unm.edu.
Joel UpstonDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Elizabeth Grace MayerDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Thomas JonesDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Andrew A MaudsleyDepartment of Radiology, University of Miami, FL, NM, USA.ORCID http://orcid.org/0000-0001-7653-3063
Charles GasparovicMind Research Network, Albuquerque, NM, USA.
Mauricio TohenDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Rhoshel LenrootDepartments of Psychiatry, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
University of New Mexico · USMind Research Network · USUniversity of Miami · US

Funding

NEURAL MECHANISMS OF SCHIZOPHRENIAP20RR021938 · NCRR · THE MIND RESEARCH NETWORK · PI HANLON, FAITH MARIE · 2008 to 2011
$9.4M
UNIVERSITY OF NEW MEXICO CLINICAL AND TRANSLATIONAL SCIENCE CENTERUL1RR031977 · NCRR · UNIVERSITY OF NEW MEXICO · PI LARSON, RICHARD S · 2010 to 2011
$8.8M
Brain Glutamate and Outcome in SchizophreniaR01MH084898 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BUSTILLO, JUAN RICARDO · 2009 to 2013
$1.7M
NIMH NIH HHS R01 MH084898U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) 3 UL1 RR031977-02S2U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) P20 RR021938-01A1U.S. Department of Health & Human Services | NIH | National Center for Research Resources (NCRR) R01 EB01606U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH084898
6 · The paper itself

Abstract

Proton magnetic resonance spectroscopy (

Indexed as

ProtonsSchizophreniaAspartic AcidCreatineGlutamic AcidGlutamineHumansProton Magnetic Resonance SpectroscopyAspartic AcidCreatineGlutamic AcidGlutamineProtons

Identifiers

PMID32403117
PMCPMC7608301
OpenAlexW3024587359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.