Evidence map›Paper›PMID 32403084›Full record

ArticleEBioMedicine2020

Sex-dependent associations between addiction-related behaviors and the microbiome in outbred rats.

Veronica L Peterson, Jerry B Richards, Paul J Meyer, Raul Cabrera-Rubio, Jordan A Tripi, Christopher P King, Oksana Polesskaya, Amelie Baud, Apurva S Chitre, Thomaz F S Bastiaanssen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Veronica L PetersonAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Room 2.33, 2nd Floor, Western Gateway Building, Cork, Ireland.
Jerry B RichardsDepartment of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, USA.
Paul J MeyerDepartment of Psychology, University at Buffalo, Buffalo, NY, USA.
Raul Cabrera-RubioAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Jordan A TripiDepartment of Psychology, University at Buffalo, Buffalo, NY, USA.
Christopher P KingDepartment of Psychology, University at Buffalo, Buffalo, NY, USA.
Oksana PolesskayaDepartment of Psychiatry, University of California San Diego, CA, USA.
Amelie BaudDepartment of Psychiatry, University of California San Diego, CA, USA.
Apurva S ChitreDepartment of Psychiatry, University of California San Diego, CA, USA.
Thomaz F S BastiaanssenAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Room 2.33, 2nd Floor, Western Gateway Building, Cork, Ireland.
Leah Solberg WoodsWake Forest University Winston-Salem, NC, USA.
Fiona CrispieAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Timothy G DinanAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland.
Paul D CotterAPC Microbiome Ireland, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark, Fermoy, Cork, Ireland.
Abraham A PalmerDepartment of Psychiatry, University of California San Diego, CA, USA; Institute for Genomic Medicine, University of California San Diego, CA, USA; Center for Microbiome Innovation, University of California San Diego, CA, USA.
John F CryanAPC Microbiome Ireland, University College Cork, Cork, Ireland; Department of Anatomy and Neuroscience, University College Cork, Room 2.33, 2nd Floor, Western Gateway Building, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
University at Buffalo, State University of New York · USUniversity College Cork · IEUniversity of California San Diego · USTeagasc - The Irish Agriculture and Food Development Authority · IEWake Forest University · US

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
NIDA NIH HHS P50 DA037844Wellcome Trust
6 · The paper itself

Abstract

backgroundMultiple factors contribute to the etiology of addiction, including genetics, sex, and a number of addiction-related behavioral traits. One behavioral trait where individuals assign incentive salience to food stimuli ("sign-trackers", ST) are more impulsive compared to those that do not ("goal-trackers", GT), as well as more sensitive to drugs and drug stimuli. Furthermore, this GT/ST phenotype predicts differences in other behavioral measures. Recent studies have implicated the gut microbiota as a key regulator of brain and behavior, and have shown that many microbiota-associated changes occur in a sex-dependent manner. However, few studies have examined how the microbiome might influence addiction-related behaviors. To this end, we sought to determine if gut microbiome composition was correlated with addiction-related behaviors determined by the GT/ST phenotype.

methodsOutbred male (N=101) and female (N=101) heterogeneous stock rats underwent a series of behavioral tests measuring impulsivity, attention, reward-learning, incentive salience, and locomotor response. Cecal microbiome composition was estimated using 16S rRNA gene amplicon sequencing. Behavior and microbiome were characterized and correlated with behavioral phenotypes. Robust sex differences were observed in both behavior and microbiome; further analyses were conducted within sex using the pre-established goal/sign-tracking (GT/ST) phenotype and partial least squares differential analysis (PLS-DA) clustered behavioral phenotype.

resultsOverall microbiome composition was not associated to the GT/ST phenotype. However, microbial alpha diversity was significantly decreased in female STs. On the other hand, a measure of impulsivity had many significant correlations to microbiome in both males and females. Several measures of impulsivity were correlated with the genus Barnesiella in females. Female STs had notable correlations between microbiome and attentional deficient. In both males and females, many measures were correlated with the bacterial families Ruminocococcaceae and Lachnospiraceae.

conclusionsThese data demonstrate correlations between several addiction-related behaviors and the microbiome specific to sex.

Indexed as

Reinforcement, PsychologyAnimalsAnimals, Outbred StrainsBacillotaBacteroidetesCecumCocaineCocaine-Related DisordersConditioning, OperantDelay DiscountingEubacterialesEuryarchaeotaFemaleGastrointestinal MicrobiomeImpulsive BehaviorLocomotionCocaineRNA, Ribosomal, 16SAddictionGut-brain axisMicrobiomeSexSign-tracker

Identifiers

PMID32403084
PMCPMC7218262
OpenAlexW3022219464

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.