Targeting raised von Willebrand factor levels and macrophage activation in severe COVID-19: Consider low volume plasma exchange and low dose steroid.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it.

1. Endotheliopathy marked by high von Willebrand factor (vWF) antigen in COVID-19 is associated with poor outcome: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
   Pooled it
2. The association between therapeutic plasma exchange and the risk of mortality among patients critically ill with COVID-19: a meta-analysis.F1000Research · 2021
   Pooled it
3. Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics.Frontiers in neurology · 2024
   Review
4. Pathological Effects of SARS-CoV-2 Associated with Hematological Abnormalities.Current issues in molecular biology · 2023
   Review
5. Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC).eLife · 2023
   Review
6. Peripheral neurological complications during COVID-19: A single center experience.Journal of the neurological sciences · 2022
   Article
7. Gain-of-Function Variant p.Pro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics.Thrombosis and haemostasis · 2022
   Article
8. Late-onset hematological complications post COVID-19: An emerging medical problem for the hematologist.American journal of hematology · 2022
   Review
9. COVID-19 coagulopathies: Human blood proteins mimic SARS-CoV-2 virus, vaccine proteins and bacterial co-infections inducing autoimmunity: Combinations of bacteria and SARS-CoV-2 synergize to induce autoantibodies targeting cardiolipin, cardiolipin-binding proteins, platelet factor 4, prothrombin, and coagulation factors.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021
   Article
10. TEGJournal of clinical medicine · 2021
    Review
11. Von Willebrand factor: A key glycoprotein involved in thrombo-inflammatory complications of COVID-19.Chemico-biological interactions · 2021
    Review
12. Understanding the role of therapeutic plasma exchange in COVID-19: preliminary guidance and practices.Vox sanguinis · 2021
    Article
13. Long-COVID and Post-COVID Health Complications: An Up-to-Date Review on Clinical Conditions and Their Possible Molecular Mechanisms.Viruses · 2021
    Review
14. The Impact of SARS-CoV-2 Infection on the Development of Neurodegeneration in Multiple Sclerosis.International journal of molecular sciences · 2021
    Review
15. Coronavirus and Cardiovascular Disease, Myocardial Injury, and Arrhythmia: JACC Focus Seminar.Journal of the American College of Cardiology · 2020
    Review
16. Biological Factors Linking ApoE ε4 Variant and Severe COVID-19.Current atherosclerosis reports · 2020
    Article
17. A relative ADAMTS13 deficiency supports the presence of a secondary microangiopathy in COVID 19.Thrombosis research · 2020
    Article
18. Covid-19: The Rollercoaster of Fibrin(Ogen), D-Dimer, Von Willebrand Factor, P-Selectin and Their Interactions with Endothelial Cells, Platelets and Erythrocytes.International journal of molecular sciences · 2020
    Review
19. Angiotensin-converting enzyme 2, the complement system, the kallikrein-kinin system, type-2 diabetes, interleukin-6, and their interactions regarding the complex COVID-19 pathophysiological crossroads.Journal of the renin-angiotensin-aldosterone system : JRAAS
    Review
20. Recognizing Dysfunctional Innate and Adaptive Immune Responses Contributing to Liver Damage in Patients With Cirrhosis.Journal of clinical and experimental hepatology
    Review

Corrections and comments

• Comment on
  Severe COVID-19 infection associated with endothelial activation.2020

Authors and funding

7 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as