Evidence map›Paper›PMID 32402646›Full record

ReviewCurrent topics in membranes2020

Endothelial TRPV4 channels and vasodilator reactivity.

Yen-Lin Chen, Swapnil K Sonkusare

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in membranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 68 citations in OpenAlex.

  1. Lipid Regulation of Mechanosensitive Ion Channels.International journal of molecular sciences · 2026
    Review
  2. Article
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  6. Article
  7. The machinery of healthy vasodilatation: an overview.Pflugers Archiv : European journal of physiology · 2025
    Review
  8. Regulation of Collecting Lymphatic Vessel Contractile Function by TRPV4 Channels.Arteriosclerosis, thrombosis, and vascular biology · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. CaBiomedicines · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Administration of the KFrontiers in pharmacology · 2025
    Article
  18. Mechanisms and Recent Advances of Small-Molecule Therapeutics in Rosacea Treatment.Clinical, cosmetic and investigational dermatology · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yen-Lin ChenRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, United States.
Swapnil K SonkusareRobert M. Berne Cardiovascular Research Center, University of Virginia-School of Medicine, Charlottesville, VA, United States; Department of Molecular Physiology and Biological Physics, University of Virginia-School of Medicine, Charlottesville, VA, United States. Electronic address: sks2n@virginia.edu.
University of Virginia · US

Funding

Paracrine TNF signaling impairs endothelial TRPV4 microdomains in obesityR01HL142808 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$4.4M
Flow-Activated Calcium Signaling Microdomains in Small Pulmonary ArteriesR01HL146914 · NHLBI · UNIVERSITY OF VIRGINIA · PI Swapnil K. Sonkusare · 2019 to 2026
$3.8M
New Signaling Networks in Vascular Smooth MuscleR01HL147555 · NHLBI · UNIVERSITY OF VIRGINIA · PI DEREWENDA, ZYGMUNT S, SOMLYO, AVRIL V. · 2020 to 2024
$3.6M
NHLBI NIH HHS R01 HL142808NHLBI NIH HHS R01 HL146914NHLBI NIH HHS R01 HL147555
6 · The paper itself

Abstract

Transient receptor potential vanilloid 4 (TRPV4) ion channels on the endothelial cell membrane are widely regarded as a crucial Ca

Indexed as

VasodilationAnimalsDiseaseEndothelial CellsHumansSignal TransductionTRPV Cation ChannelsTRPV Cation ChannelsCalcium signalingCardiovascular diseaseEndothelial heterogeneityEndotheliumTRPV4 ion channelsVasodilation

Identifiers

PMID32402646
PMCPMC9748413
OpenAlexW3006562887

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.