Evidence map›Paper›PMID 32402640›Full record

ReviewCurrent topics in membranes2020

Ion channels and the regulation of myogenic tone in peripheral arterioles.

William F Jackson

Open access · greenAbstract readReview
In one paragraph

Review in Current topics in membranes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. Review
  2. Pacemaking in the lymphatic system.The Journal of physiology · 2026
    Review
  3. Article
  4. Review
  5. A comprehensive overview of fish envenomation and venom toxicity in Brazil.The journal of venomous animals and toxins including tropical diseases · 2025
    Article
  6. Insulin resistance, CaFrontiers in physiology · 2025
    Review
  7. Endothelial KAmerican journal of physiology. Heart and circulatory physiology · 2023
    Article
  8. Vascular mechanotransduction.Physiological reviews · 2023
    Review
  9. CaInternational journal of molecular sciences · 2023
    Review
  10. Oxidative Regulation of Vascular CaAntioxidants (Basel, Switzerland) · 2022
    Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William F JacksonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, MI, United States. Electronic address: jacks783@msu.edu.
Michigan State University · US

Funding

SIGNALING MECHANISMS IN ARTERIES AND VEINS IN HYPERTENSIONP01HL070687 · NHLBI · MICHIGAN STATE UNIVERSITY · PI WATTS, STEPHANIE W · 2003 to 2019
$22.8M
Cerebral parenchymal arteriole dysfunction and cognitive decline in a life-long high fat feeding modelR01HL137694 · NHLBI · MICHIGAN STATE UNIVERSITY · PI DORRANCE, ANNE M., JACKSON, WILLIAM F. · 2017 to 2020
$2.1M
CONTROL OF MICROVASCULAR FUNCTION BY OXYGENR01HL032469 · NHLBI · WESTERN MICHIGAN UNIVERSITY · PI JACKSON, WILLIAM F. · 1987 to 2006
$1.1M
NHLBI NIH HHS P01 HL070687NHLBI NIH HHS R01 HL032469NHLBI NIH HHS R01 HL137694
6 · The paper itself

Abstract

Myogenic tone is a hall-mark feature of arterioles in the microcirculation. This pressure-induced, contractile activation of vascular smooth muscle cells (VSMCs) in the wall of these microvessels importantly contributes to the regulation and maintenance of blood pressure; blood flow to and within organs and tissues; and capillary pressure and fluid balance. Ion channels play a central role in the genesis and maintenance of myogenic tone. Mechanosensitive ion channels such as TRPC6 may serve as one of the sensors of pressure-induced membrane stress/strain, and TRPC6 along with TRPM4 channels are responsible pressure-induced VSMC depolarization that may be bolstered by the activity of Ca

Indexed as

Muscle DevelopmentAnimalsArteriolesCalciumHumansIon ChannelsMuscle, Smooth, VascularCalciumIon ChannelsArteriolesBlood pressureCalcium channelsIon channelsMicrocirculationMyogenic tonePotassium channelsTRP channelsVascular smooth muscle cellsVasoconstriction

Identifiers

PMID32402640
PMCPMC8577286
OpenAlexW3007793974

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.