Evidence map›Paper›PMID 32402544›Full record

ArticleBrachytherapy

Quality comparison between three-dimensional T2-weighted SPACE and two-dimensional T2-weighted turbo spin echo magnetic resonance images for the brachytherapy planning evaluation of prostate and periprostatic anatomy.

Tharakeswara K Bathala, Aradhana M Venkatesan, Jingfei Ma, Priyadarshini Bhosale, Wei Wei, Rajat J Kudchadker, Jihong Wang, Mitchell S Anscher, Chad Tang, Teresa L Bruno and 2 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brachytherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tharakeswara K BathalaDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: tkbathala@mdanderson.org.
Aradhana M VenkatesanDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jingfei MaDepartment of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Priyadarshini BhosaleDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.
Wei WeiCancer Biostatistics Section, Taussig Cancer Institute, Cleveland Clinic, Cleveland, OH.
Rajat J KudchadkerDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Jihong WangDepartment of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX.
Mitchell S AnscherDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Chad TangDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Teresa L BrunoDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Steven J FrankDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.
Janio SzklarukDepartment of Abdominal Imaging, The University of Texas MD Anderson Cancer Center, Houston, TX.

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

purposeThe purpose of this study was to compare an isotropic three-dimensional (3D) T2-weighted sequence sampling perfection with application-optimized contrasts by using flip angle evolution (SPACE) with an axial two-dimensional T2-weighted turbo spin echo (TSE) sequence with regard to overall image quality and the delineation of normal prostate and periprostatic anatomy for low-dose-rate prostate cancer brachytherapy planning evaluation. METHODS AND MATERIALS: Patients (n = 69) with prostate cancer who had pelvic magnetic resonance imaging (MRI) for low-dose-rate brachytherapy treatment planning were included. Three radiologists independently assessed the visibility of nine anatomic structures on each sequence by using a 5-point scale and overall image quality by using a 4-point scale. The significance of the differences in diagnostic performance was tested with a Wilcoxon signed rank test.

resultsNo significant intersequence differences were found for most (7/9) anatomical structures and overall image quality. The mean scores for visibility of anatomical structures on the 3D SPACE and 2D TSE sequences, respectively, were as follows: the zonal anatomy (3.7; 3.9, p = 0.05), prostate capsule (3.9; 4.0, p = 0.08), neurovascular bundle (2.9; 2.9, p = 0.9), rectoprostatic angle (3.8; 3.8, p = 0.35), rectum (4.2; 4.3, p = 0.26), urethra (3.8; 3.9, p = 0.12), urinary bladder (4.6; 4.6, p = 0.61), and overall image quality (2.9; 2.9, p = 0.33). 3D SPACE was superior for delineation of the genitourinary diaphragm (3.8; 3.6, p = 0.003), whereas 2D TSE was superior for delineation of the seminal vesicles (3.5; 4.0, p < 0.0001).

conclusionsAnatomic delineation of the prostatic and periprostatic anatomy provided by the 3D SPACE sequence is as robust in quality as that provided by a conventional 2D TSE sequence with superior delineation of the genitourinary diaphragm. For MRI-based brachytherapy treatment planning, the 3D SPACE sequence with subcentimeter isotropic resolution can replace the 2D TSE sequence and be incorporated into standard MRI protocols.

Indexed as

BrachytherapyRadiotherapy Planning, Computer-AssistedAgedAnatomic LandmarksBlood VesselsContrast MediaHumansImaging, Three-DimensionalMagnetic Resonance ImagingMaleMiddle AgedPeripheral NervesProstatic NeoplasmsRectumRetrospective StudiesSeminal VesiclesContrast Media2D TSE sequence3D SPACE sequenceLow-dose-rate brachytherapyProstate brachytherapyProstate magnetic resonance imaging

Identifiers

PMID32402544
PMCPMC7368804

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.