ArticleCell metabolism2020
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.
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Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 388 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
388citing papers in PubMed, 2 pooled it
46.8field-weighted citation impact, top 1% of its field
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Who cites it
388 citing papers in PubMed, 2 syntheses or guidelines pooled it, 582 citations in OpenAlex.
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- Systematic review and meta-analysis of current guidelines, and their evidence base, on risk of renal function after administration of contrast medium for diabetic patients receiving metformin.Frontiers in medicine · 2025Pooled it
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- Metformin alleviates aging-associated periodontitis via NRF2-mediated restoration of the IRE1α dependent unfolded protein response.Bioactive materials · 2026Article
- Reprogramming Autophagy to Strengthen Antitumour Immunity: Advances in Immunotherapeutic Strategies.Immunology · 2026Review
- Schisandra chinensis polysaccharide attenuates diabetic islet cell injury by promoting autophagy via suppression of the PI3K/AKT/mTOR signaling cascade.Journal of molecular histology · 2026Article
- Drug-Induced Reduction in 80Q Aggregates in aBiomedicines · 2026Article
- A Randomized Clinical Trial: Daily Photoprotection With a Combined Sunscreen-Antioxidant Formulation Preserves Mitochondrial DNA Integrity in Human Facial Skin In Vivo.The Journal of clinical and aesthetic dermatology · 2026Article
- Aging-Related Changes in the Injury Response of the Peripheral Nervous System.Neuroscience bulletin · 2026Review
- Trophoblast aging driven by IL33 deficiency elevates recurrent pregnancy loss risk through SNAP29 lactylation-mediated autophagy impairment.Autophagy · 2026Article
- Immunosenescence in systemic and multi-organ aging: mechanisms, inter-organ crosstalk, and translational opportunities.npj aging · 2026Review
- The p97 adaptor p47/NSFL1C is necessary for stress granule dissolution after heat stress.bioRxiv : the preprint server for biology · 2026Article
- Antiaging Effects of Mannose-6-Phosphate through Enhanced Mitochondrial Function and Collagen Remodeling.ACS omega · 2026Article
- Metformin beyond Glycemic Control: New Mechanistic Insights and Expanding Therapeutic Horizons.Diabetes & metabolism journal · 2026Review
- Lifelong Exercise as a Modulator of CD4European journal of clinical investigation · 2026Review
- Sex- and age-dependent mitochondrial dysfunction and cognitive impairment in a mouse model of familial hypercholesterolemia.Biology of sex differences · 2026Article
- Role of Succinate Dehydrogenase in Age-Related Th17 Inflammation.Aging cell · 2026Article
328 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on byCD42020
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Authors and funding
21 authors at 5 institutions in 1 country.
Leena P BharathDepartment of Nutrition and Public Health, Merrimack College, North Andover, MA, USA.
Madhur AgrawalDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA.
Grace McCambridgeDepartment of Nutrition and Public Health, Merrimack College, North Andover, MA, USA.
Dequina A NicholasDepartment of Obstetrics, Gynecology, and Reproductive Sciences, School of Medicine, University of California, San Diego, San Diego, CA, USA.
Hatice HasturkForsyth Institute, Cambridge, MA, USA.
Jing LiuDepartment of Computer Science, University of Kentucky, Lexington, KY, USA.
Kai JiangDepartment of Physiology, University of Kentucky, Lexington, KY, USA.
Rui LiuDepartment of Pharmaceutical Sciences, University of Kentucky, Lexington, KY, USA.
Zhenheng GuoDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA.
Jude DeeneyDepartment of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA.
Caroline M ApovianDepartment of Medicine, Endocrinology, Diabetes & Nutrition, Boston University School of Medicine, Boston, MA, USA.
Jennifer Snyder-CappioneDepartment of Microbiology, Boston University School of Medicine, Boston, MA, USA; Flow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.
Gregory S HawkDepartment of Statistics, University of Kentucky, Lexington, KY, USA.
Rebecca M FleemanDepartments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA.
Riley M F PihlFlow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA.
Katherine ThompsonDepartment of Statistics, University of Kentucky, Lexington, KY, USA.
Anna C BelkinaFlow Cytometry Core Facility, Boston University School of Medicine, Boston, MA, USA; Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA, USA.
Licong CuiDepartment of Computer Science, University of Kentucky, Lexington, KY, USA; School of Biomedical Informatics, University of Texas Health Science Center at Houston, Houston, TX, USA.
Elizabeth A ProctorDepartments of Neurosurgery and Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA; Departments of Biomedical Engineering, and Engineering Science & Mechanics and Center for Neural Engineering, Pennsylvania State University, University Park, PA, USA.
Philip A KernBarnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA; Department of Medicine, University of Kentucky, Lexington, KY, USA.
Barbara S NikolajczykDepartment of Pharmacology and Nutritional Sciences, University of Kentucky, Lexington, KY, USA; Barnstable Brown Diabetes and Obesity Center, University of Kentucky, Lexington, KY, USA. Electronic address: barb.nik@uky.edu.
University of Kentucky · USBoston University · USMerrimack College · USPennsylvania State University · USUniversity of California San Diego · US
Funding
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7MUniversity of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI KATHLEEN L. O'CONNOR · 2013 to 2026
$38.3MKentucky Center for Clinical and Translational ScienceUL1TR001998 · NCATS · UNIVERSITY OF KENTUCKY · PI HARTMANN, KATHERINE E, KERN, PHILIP A · 2016 to 2025
$34.2MTransgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI GREENBERG, ANDREW S, PERISSI, VALENTINA · 1992 to 2021
$25.0MTRAINING PROGRAM IN ENDOCRINE AND METABOLIC RESEARCHT32DK007201 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CORKEY, BARBARA E., KANDROR, KONSTANTIN V · 1986 to 2023
$6.4MInflammation in human obesity and type 2 diabetesR01DK108056 · NIDDK · UNIVERSITY OF KENTUCKY · PI LAUFFENBURGER, DOUGLAS A, NIKOLAJCZYK, BARBARA · 2016 to 2019
$2.6MRoles for lymphocyte RANKL in periodontal complications of type 2 diabetesU01DE025383 · NIDCR · UNIVERSITY OF KENTUCKY · PI NIKOLAJCZYK, BARBARA, VAN DYKE, THOMAS ELLIOTT · 2018 to 2020
$1.7MBoston University Inflammatory Disorders Training GrantT32AI089673 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WETZLER, LEE MARK · 2011 to 2015
$1.4MRoles for lymphocyte RANKL in periodontal complications of type 2 diabetesR01DE025383 · NIDCR · UNIVERSITY OF KENTUCKY · PI NIKOLAJCZYK, BARBARA, VAN DYKE, THOMAS ELLIOTT · 2016 to 2017
$1.2MNCATS NIH HHS UL1 TR001998NCI NIH HHS P30 CA177558NIAID NIH HHS P30 AI042853NIAID NIH HHS T32 AI089673NIDCR NIH HHS R01 DE025383NIDCR NIH HHS U01 DE025383NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK108056NIDDK NIH HHS T32 DK007201
Abstract
Age is a non-modifiable risk factor for the inflammation that underlies age-associated diseases; thus, anti-inflammaging drugs hold promise for increasing health span. Cytokine profiling and bioinformatic analyses showed that Th17 cytokine production differentiates CD4
Indexed as
AdultAgingAutophagyHumansHypoglycemic AgentsInflammationMetforminMiddle AgedMitochondriaHypoglycemic AgentsMetforminautophagyinflammagingmetforminmitochondriaT cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.