ArticleCell stem cell2020
RNA Demethylase ALKBH5 Selectively Promotes Tumorigenesis and Cancer Stem Cell Self-Renewal in Acute Myeloid Leukemia.
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In one paragraph
Article in Cell stem cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 240 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
240citing papers in PubMed, 1 pooled it
20.5field-weighted citation impact, top 1% of its field
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Who cites it
240 citing papers in PubMed, 1 synthesis or guideline pooled it, 375 citations in OpenAlex.
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- Intrinsically disordered regions restrain genomic targeting of RNA and histone demethylases in mammals and plants.Nature genetics · 2026Article
- Role and prognostic value of N6-methyladenosine RNA modification regulators in glycolytic reprogramming during sepsis.Journal of intensive care · 2026Article
- Interplay between N6-methyladenosine RNA methylation and protein lactylation: a novel crosstalk linking metabolism and epigenetic regulation in human diseases.Journal of translational medicine · 2026Review
- Can Disruption of Circadian Rhythms Be Linked to Radiation-Induced Acute Myeloid Leukaemia?Cancers · 2026Review
- Chromosomal rearrangement-enhanced mRNA stability drives the oncogenic potential of fusion genes in pediatric leukemia.Haematologica · 2026Article
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- m6A Modification of ATOX1 Inhibits Acute Myeloid Leukemia Progression by Promoting Cuproptosis.Cancer research communications · 2026Article
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- Tendon Organoids Enable Functional Tendon Rejuvenation Through ALKBH5-Dependent RNA Demethylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Targeting RNA binding proteins with small-molecule inhibitors: Advances, challenges, and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- m6A RNA modification and its emerging roles in diseases: recent advances and therapeutic implications.Journal of translational medicine · 2026Review
- RMzyme: regulations of RNA-modifying enzymes in humans.Signal transduction and targeted therapy · 2026Article
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180 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 7 institutions in 2 countries.
Chao ShenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Yue ShengDepartment of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32608, USA.
Allen C ZhuDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Medical Scientist Training Program/Committee on Cancer Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA.
Sean RobinsonDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Xi JiangDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Pharmacology, and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Institute of Hematology, Zhejiang University, and Zhejiang Engineering Laboratory for Stem Cell and Immunotherapy, Hangzhou 310058, Zhejiang Province, China.
Lei DongDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Huiying ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Rui SuDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Zhe YinDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA; Department of Thoracic Surgery, Chongqing Cancer Hospital, Chongqing 400030, China.
Wei LiDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Xiaolan DengDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Yinhuai ChenTransgenic Animal and Genome Editing Facility, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Yueh-Chiang HuTransgenic Animal and Genome Editing Facility, Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Hengyou WengDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Huilin HuangDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Emily PrinceDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Christopher R CogleDepartment of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32608, USA.
Miao SunDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Bin ZhangDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Chun-Wei ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Guido MarcucciDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA.
Chuan HeDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, Medical Scientist Training Program/Committee on Cancer Biology, Howard Hughes Medical Institute, University of Chicago, Chicago, IL 60637, USA. Electronic address: chuanhe@uchicago.edu.
Zhijian QianDepartment of Medicine and Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32608, USA. Electronic address: zhijian.qian@medicine.ufl.edu.
Jianjun ChenDepartment of Systems Biology, Beckman Research Institute of City of Hope, Monrovia, CA 91016, USA. Electronic address: jianchen@coh.org.
Beckman Research InstituteCity of Hope · USUniversity of Florida · USUniversity of Cincinnati Medical Center · USCincinnati Children's Hospital Medical Center · USHoward Hughes Medical Institute · USUniversity of Chicago · US
Funding
Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3MMEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MTranscriptome-wide base-resolution sequencing of pseudouridine in human normal and AD brain tissues-CEGS Admin supplement 2020-2021RM1HG008935 · NHGRI · UNIVERSITY OF CHICAGO · PI HE, CHUAN · 2016 to 2025
$24.4MTargeting FTO to treat acute myeloid leukemiaR01CA243386 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2020 to 2024
$2.8MCombinational Targeting the Feed-forward Epigenetic Circuitry in Mixed Lineage LeukemiaR37CA233691 · NCI · MAYO CLINIC ROCHESTER · PI CHEN, CHUN-WEI DAVID · 2019 to 2025
$2.8MThe role and mechanism of METTL3/METTL14-mediated RNA modification in the pathogenesis and drug-resistance of AMLR01CA236399 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, JIANJUN · 2019 to 2023
$2.3MTargeting TET1 signaling to treat acute myeloid leukemiaR01CA211614 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.3MRole of BAZ2A in MLL-r leukemia and therapeutic responseR01CA236626 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, CHUN-WEI DAVID · 2019 to 2023
$2.2MThe role and mechanism of FTO in leukemogenesis and drug responseR01CA214965 · NCI · UNIVERSITY OF CINCINNATI · PI CHEN, JIANJUN · 2017 to 2021
$2.1MThe role of EVI1-induced hypermethylation in leukemogenesis.R01HL131444 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI QIAN, ZHIJIAN · 2016 to 2019
$1.6MThe molecular mechanism of clonal dominance in 5q(del) MDSR01DK107615 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI QIAN, ZHIJIAN · 2016 to 2019
$1.4MEpigenetic mechanisms for oncogene silencing in MLL-rearranged leukemiaR00CA197498 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI CHEN, CHUN-WEI DAVID · 2017 to 2019
$747kHoward Hughes Medical InstituteNCI NIH HHS F30 CA247175NCI NIH HHS P30 CA033572NCI NIH HHS R00 CA197498NCI NIH HHS R01 CA211614NCI NIH HHS R01 CA214965NCI NIH HHS R01 CA236399NCI NIH HHS R01 CA236626NCI NIH HHS R01 CA243386NCI NIH HHS R37 CA233691NHGRI NIH HHS RM1 HG008935NHLBI NIH HHS R01 HL131444NIDDK NIH HHS R01 DK107615NIGMS NIH HHS T32 GM007281
Abstract
N
Indexed as
Cell Self RenewalLeukemia, Myeloid, AcuteAlkB Homolog 5, RNA DemethylaseCarcinogenesisHumansMicrotubule-Associated ProteinsNeoplastic Stem CellsALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseMicrotubule-Associated ProteinsTACC3 protein, humanacute myeloid leukemiaALKBH5hematopoietic stem cells (HSCs)leukemia stem cells (LSCs/LICs)m(6)A modificationMYCnormal hematopoiesisP21prognosisTACC3
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