Evidence map›Paper›PMID 32402248›Full record

ArticleStructure (London, England : 1993)2020

Activation of Phospholipase C β by Gβγ and Gα

Isaac J Fisher, Meredith L Jenkins, Gregory G Tall, John E Burke, Alan V Smrcka

Open access · bronzeAbstract read
In one paragraph

Article in Structure (London, England : 1993), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Anionic lipids regulate PLCbioRxiv : the preprint server for biology · 2026
    Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Coincident Regulation of PLCMolecular pharmacology · 2022
    Article
  14. Control of GαScience advances · 2022
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Isaac J FisherDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Department of Pharmacology and Physiology, University of Rochester School of Medicine, Rochester, NY 14629, USA.
Meredith L JenkinsDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada.
Gregory G TallDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
John E BurkeDepartment of Biochemistry and Microbiology, University of Victoria, Victoria, BC V8W 2Y2, Canada. Electronic address: jeburke@uvic.ca.
Alan V SmrckaDepartment of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: avsmrcka@umich.edu.
University of Michigan · USUniversity of Victoria · CA

Funding

Understanding and Manipulating Phospholipase C and G Protein beta gamma subunit Signaling NetworksR35GM127303 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alan V. Smrcka · 2018 to 2026
$4.8M
Regulation of Heterotrimeric G proteins by non-receptor activatorsR01GM088242 · NIGMS · UNIVERSITY OF ROCHESTER · PI TALL, GREGORY GORDON · 2009 to 2022
$4.2M
NIGMS NIH HHS R01 GM088242NIGMS NIH HHS R35 GM127303
6 · The paper itself

Abstract

Phospholipase C (PLC) enzymes hydrolyze phosphoinositide lipids to inositol phosphates and diacylglycerol. Direct activation of PLCβ by Gα

Indexed as

Allosteric RegulationAnimalsBinding SitesChlorocebus aethiopsCOS CellsGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPhospholipase C betaProtein BindingSf9 CellsSpodopteraGTP-Binding Protein alpha Subunits, Gq-G11GTP-Binding Protein beta SubunitsGTP-Binding Protein gamma SubunitsPhospholipase C betaGPCRG proteinG-protein-coupled receptorGαqGβγHDX-MShydrogen-deuterium exchangelipidsmembrane interactionsphospholipase Cprotein dynamicssignal transduction

Identifiers

PMID32402248
PMCPMC7891876
OpenAlexW3024889382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.