ArticleBiophysical journal2020
Intercellular Sodium Regulates Repolarization in Cardiac Tissue with Sodium Channel Gain of Function.
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Article in Biophysical journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Cardiac Impulse Propagation: An Integrated View.JACC. Basic to translational science · 2026Review
- Ephaptic coupling and the source-sink effect of cardiac conduction.The Journal of physiology · 2026Article
- Gap junctional and ephaptic coupling in cardiac electrical propagation: homocellular and heterocellular perspectives.The Journal of physiology · 2026Review
- Hypernatremia Enhances Transient Outward Potassium and Late Sodium Currents in a Mouse Model of Long QT Syndrome Type 3.bioRxiv : the preprint server for biology · 2025Article
- Age-Associated Perinexal Narrowing Masks Consequences of Sodium Channel Gain of Function in Guinea Pig Hearts.JACC. Clinical electrophysiology · 2025Article
- Ultrastructure and cardiac impulse propagation: scaling up from microscopic to macroscopic conduction.The Journal of physiology · 2025Review
- Sequence-Dependent Repolarization Is Modulated by Endogenous Action Potential Duration Gradients Rather Than Electrical Coupling in Ventricular Myocardium.Journal of the American Heart Association · 2025Article
- New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?Heart rhythm · 2025Review
- Mannitol and hyponatremia regulate cardiac ventricular conduction in the context of sodium channel loss of function.American journal of physiology. Heart and circulatory physiology · 2024Article
- Vascular Endothelial Barrier Protection Prevents Atrial Fibrillation by Preserving Cardiac Nanostructure.JACC. Clinical electrophysiology · 2023Article
- Extracellular Perinexal Separation Is a Principal Determinant of Cardiac Conduction.Circulation research · 2023Article
- Sodium channel subpopulations with distinct biophysical properties and subcellular localization enhance cardiac conduction.The Journal of general physiology · 2023Article
- Ephaptic Coupling as a Resolution to the Paradox of Action Potential Wave Speed and Discordant Alternans Spatial Scales in the Heart.Physical review letters · 2023Article
- Role of ephaptic coupling in discordant alternans domain sizes and action potential propagation in the heart.Physical review. E · 2023Article
- Modeling incomplete penetrance in long QT syndrome type 3 through ion channel heterogeneity: an in silico population study.American journal of physiology. Heart and circulatory physiology · 2023Article
- Article
- Automaticity in ventricular myocyte cell pairs with ephaptic and gap junction coupling.Chaos (Woodbury, N.Y.) · 2022Article
- Ephaptic Coupling Is a Mechanism of Conduction Reserve During Reduced Gap Junction Coupling.Frontiers in physiology · 2022Article
- Initiation and entrainment of multicellular automaticity via diffusion limited extracellular domains.Biophysical journal · 2021Article
- Hypernatremia and intercalated disc edema synergistically exacerbate long-QT syndrome type 3 phenotype.American journal of physiology. Heart and circulatory physiology · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Madison B NowakDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia.
Amara Greer-ShortDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio; Translational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia.
Xiaoping WanDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Xiaobo WuTranslational Biology, Medicine, and Health Graduate Program, Virginia Polytechnic Institute and State University, Blacksburg, Virginia; Fralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Polytechnic Institute and State University, Roanoke, Virginia.
Isabelle DeschênesDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio; Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio.
Seth H WeinbergDepartment of Biomedical Engineering, The Ohio State University, Columbus, Ohio; Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, Virginia. Electronic address: weinberg.147@osu.edu.
Steven PoelzingFralin Biomedical Research Institute at Virginia Tech Carilion, Virginia Polytechnic Institute and State University, Roanoke, Virginia; Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia. Electronic address: poelzing@vtc.vt.edu.
The Ohio State University · USVirginia Tech · USBiomedical Research Institute · USCase Western Reserve University · US
Funding
Sodium Channels and Cardiac ArrhythmiasR01HL094450 · NHLBI · OHIO STATE UNIVERSITY · PI DESCHENES, ISABELLE · 2010 to 2022
$4.0MRole of the Extracellular Space as a Modulator of the Cardiac Gap Junction - Conduction Velocity RelationshipR01HL102298 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN · 2011 to 2020
$3.9MSignaling in Inherited and Acquired Sodium Channel Gain of FunctionR01HL138003 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI POELZING, STEVEN, WEINBERG, SETH HOWARD · 2018 to 2021
$2.6MThe Role of the Sodium Channel Beta Subunit in Cardiac ConductionR01HL141855 · NHLBI · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI GOURDIE, ROBERT G, POELZING, STEVEN · 2018 to 2021
$1.8MNHLBI NIH HHS R01 HL094450NHLBI NIH HHS R01 HL102298NHLBI NIH HHS R01 HL138003NHLBI NIH HHS R01 HL141855
Abstract
In cardiac myocytes, action potentials are initiated by an influx of sodium (Na
Indexed as
Pharmaceutical PreparationsSodiumAction PotentialsGain of Function MutationIonsMyocytes, CardiacSodium ChannelsIonsPharmaceutical PreparationsSodiumSodium Channels
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.