Evidence map›Paper›PMID 32402087›Full record

ArticleRheumatology (Oxford, England)2020

Long-term outcomes and disease course of children with juvenile idiopathic arthritis in the ReACCh-Out cohort: a two-centre experience.

Amieleena Chhabra, Cal Robinson, Kristin Houghton, David A Cabral, Kimberly Morishita, Lori B Tucker, Ross E Petty, Maggie Larché, Michelle Batthish, Jaime Guzman

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Amieleena ChhabraDepartment of Pediatrics, University of British Columbia.
Cal RobinsonMcMaster University, Hamilton, Ontario, Canada.
Kristin HoughtonDepartment of Pediatrics, University of British Columbia.
David A CabralDepartment of Pediatrics, University of British Columbia.
Kimberly MorishitaDepartment of Pediatrics, University of British Columbia.
Lori B TuckerDepartment of Pediatrics, University of British Columbia.
Ross E PettyDepartment of Pediatrics, University of British Columbia.
Maggie LarchéMcMaster University, Hamilton, Ontario, Canada.
Michelle BatthishMcMaster University, Hamilton, Ontario, Canada.
Jaime GuzmanDepartment of Pediatrics, University of British Columbia.
BC Children's Hospital · CAUniversity of British Columbia · CAMcMaster University · CAMcMaster Children's Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess long-term outcomes of children with JIA diagnosed in the biologic era.

methodsChart review of patients prospectively enrolled in the Research in Arthritis in Canadian Children Emphasizing Outcomes inception cohort at two Canadian centres. Inactive disease and remission were defined according to Wallace criteria.

resultsWe included 247 of 254 (97%) eligible patients diagnosed 2005-10. At the last follow-up visit at a median age of 16.9 years, 47% were in remission off medications, 25% in remission on medications and 27% had active disease; 51% were on at least one anti-rheumatic medication (22% on biologics). Patients with systemic JIA had the highest frequency of remission off medications (70%) and patients with RF-positive polyarthritis had the lowest (18%) (P <0.05 by Fisher's exact test). Among 99 patients with oligoarthritis at enrolment, 14 (14%) had an oligoarthritis extended course. Forty-five patients (18%) had at least one erosion or joint space narrowing in X-rays or MRI, and two (0.8%) required joint replacement.

conclusionRelative to historical cohorts, this study suggests a reduction in JIA permanent damage, a more favourable prognosis for systemic JIA and a lower progression to oligoarthritis extended category. However, in an era of biologic therapy, one in four patients with JIA still enter adulthood with active disease and one in two still on treatment.

Indexed as

AdolescentAntirheumatic AgentsArthritis, JuvenileBritish ColumbiaCohort StudiesFemaleHumansMaleOntarioRemission InductionAntirheumatic Agentsbiological therapyjuvenile idiopathic arthritisprognosis

Identifiers

PMID32402087
PMCPMC7733713
OpenAlexW3025695163

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.