Evidence map›Paper›PMID 32401870›Full record

ArticleRevista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)

Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study.

Fabiano G Nery, Anna R Wilson, Marguerite R Schneider, Jeffrey R Strawn, Luis R Patino, Robert K McNamara, Caleb M Adler, Stephen M Strakowski, Melissa P DelBello

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Antidepressants, genetic risk, and the prevention of bipolar disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fabiano G NeryDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-4511-3634
Anna R WilsonDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Marguerite R SchneiderHarvard Longwood Psychiatry Residency Training Program, Boston, MA, USA.
Jeffrey R StrawnDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Luis R PatinoDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Robert K McNamaraDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Caleb M AdlerDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Stephen M StrakowskiDepartment of Psychiatry, Dell Medical School, University of Texas at Austin, Austin, TX, USA.
Melissa P DelBelloDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID http://orcid.org/0000-0003-1837-4126
University of Cincinnati Medical Center · USHarvard Affiliated Emergency Medicine Residency · USThe University of Texas at Austin · US

Funding

U of Cincinnati Bipolar Disorder Imaging & Treatment Research Center (BITREC)P50MH077138 · NIMH · UNIVERSITY OF CINCINNATI · PI STRAKOWSKI, STEPHEN M · 2007 to 2011
$9.6M
Neurochemical Effects of Omega-3 Fatty Acids in Adolescents at Risk for ManiaR34MH083924 · NIMH · UNIVERSITY OF CINCINNATI · PI DELBELLO, MELISSA P, MCNAMARA, ROBERT K. · 2009 to 2011
$704k
NIMH NIH HHS P50 MH077138NIMH NIH HHS R34 MH083924
6 · The paper itself

Abstract

objectivesTo prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder.

methodsYouth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion).

resultsMultivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion.

conclusionsCaution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder.

Indexed as

Bipolar DisorderMajor Depressive DisorderAdolescentAdultChildDiagnostic and Statistical Manual of Mental DisordersHumansParentsProspective StudiesYoung Adult

Identifiers

PMID32401870
PMCPMC7524417
OpenAlexW3024658267

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.