ArticlePloS one2020
Likely questionnaire-diagnosed food allergy in 78, 890 adults from the northern Netherlands.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Genome-Wide Association Study Reveals a Causal Relationship Between Allergic Rhinitis and Hazelnut Allergy.Allergy · 2025Pooled it
- Pooled it
- Association of atopic multimorbidity with childhood pet exposure and caesarean section delivery: a retrospective study from the Lifelines Cohort Study.Skin health and disease · 2026Article
- Functional and internalizing disorders co-aggregate with cardiometabolic and immune-related diseases within families: a population-based cohort study.BMC medicine · 2025Article
- Associations between autistic and comorbid somatic problems of gastrointestinal disorders, food allergy, pain, and fatigue in adults.Autism : the international journal of research and practice · 2024Article
- Eczema in early childhood increases the risk of allergic multimorbidity.Clinical and translational allergy · 2024Article
- Reported food-related symptoms and food allergen sensitization in a selected adult population in Hyderabad, India: A hospital-based survey.The journal of allergy and clinical immunology. Global · 2024Article
- Food allergy outside the eight big foods in Europe: A systematic review and meta-analysis.Clinical and translational allergy · 2024Review
- Insights into self-reported food allergies in Romanian schoolchildren.Frontiers in allergy · 2024Article
- The dilemma of open or double-blind food challenges in diagnosing food allergy in children: Design of the ALDORADO trial.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is challenging to define likely food allergy (FA) in large populations which limited the number of large studies regarding risk factors for FA.
objectiveWe studied the prevalence and characteristics of self-reported FA (s-rFA) in the large, population-based Dutch Lifelines cohort and identified associated risk factors.
methodsLikely food allergic cases (LikelyFA) were classified based on questionnaire reported characteristics consistent with FA. Subjects with atypical characteristics were classified as Indeterminate. We investigated 13 potential risk factors for LikelyFA such as birth mode and living on a farm and addressed health-related quality of life (H-RQOL).
resultsOf the 78, 890 subjects, 12.1% had s-rFA of which 4.0% and 8.1% were classified as LikelyFA and Indeterminate, respectively. Younger age, female sex, asthma, eczema and nasal allergy increased the risk of LikelyFA (p-value range <1.00*10-250-1.29*10-7). Living in a small city/large village or suburb during childhood was associated with a higher risk of LikelyFA than living on a farm (p-value = 7.81*10-4 and p = 4.84*10-4, respectively). Subjects classified as Indeterminate more often reported depression and burn-out compared to those without FA (p-value = 1.46*10-4 and p = 8.39*10-13, respectively). No association was found with ethnicity, (duration of) breastfeeding, birth mode and reported eating disorder. Mental and physical component scores measuring H-RQOL were lower in both those classified as LikelyFA and Indeterminate compared to those without FA.
conclusionThe prevalence of s-rFA among adults is considerable and one-third reports characteristics consistent with LikelyFA. Living on a farm decreased the risk of LikelyFA. The association of poorer H-RQOL as well as depression and burn-out with questionable self-perceived FA is striking and a priority for future study.
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