ArticleRadiation research2020
Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio.
Article in Radiation research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Evaluation of radiation damage effects of low-energy Auger and conversion electrons emitted byScientific reports · 2026Article
- A polymer physics model of the interphase cell nucleus for radiobiological simulations.Scientific reports · 2026Article
- TOPAS-Tissue: A Framework for the Simulation of the Biological Response to Ionizing Radiation at the Multi-Cellular Level.International journal of molecular sciences · 2024Article
- A mechanistic simulation of induced DNA damage in a bacterial cell by X- and gamma rays: a parameter study.Physical and engineering sciences in medicine · 2024Article
- Simulation of Radiation-Induced DNA Damage and Protection by Histones Using the Code RITRACKS.Biotech (Basel (Switzerland)) · 2024Article
- A spatial measure-valued model for radiation-induced DNA damage kinetics and repair under protracted irradiation condition.Journal of mathematical biology · 2024Article
- Effects of Differing Underlying Assumptions in In Silico Models on Predictions of DNA Damage and Repair.Radiation research · 2023Article
- Estimation of relative biological effectiveness ofEJNMMI physics · 2023Article
- High-LET radiation induces large amounts of rapidly-repaired sublethal damage.Scientific reports · 2023Article
- A fast Monte Carlo cell-by-cell simulation for radiobiological effects in targeted radionuclide therapy using pre-calculated single-particle track standard DNA damage data.Frontiers in nuclear medicine · 2023Article
- Cellular lethal damage ofFrontiers in medicine · 2023Article
- The complexity of DNA damage by radiation follows a Gamma distribution: insights from the Microdosimetric Gamma Model.Frontiers in oncology · 2023Article
- Nano-scale simulation of neuronal damage by galactic cosmic rays.Physics in medicine and biology · 2022Article
- Impact of DNA Geometry and Scoring on Monte Carlo Track-Structure Simulations of Initial Radiation-Induced Damage.Radiation research · 2022Article
- TOPAS-nBio simulation of temperature-dependent indirect DNA strand break yields.Physics in medicine and biology · 2022Article
- Nanoscale Calculation of Proton-Induced DNA Damage Using a Chromatin Geometry Model with Geant4-DNA.International journal of molecular sciences · 2022Article
- TOPAS-nBio validation for simulating water radiolysis and DNA damage under low-LET irradiation.Physics in medicine and biology · 2021Article
- The relation between microdosimetry and induction of direct damage to DNA by alpha particles.Physics in medicine and biology · 2021Article
- Multi-scale Monte Carlo simulations of gold nanoparticle-induced DNA damages for kilovoltage X-ray irradiation in a xenograft mouse model using TOPAS-nBio.Cancer nanotechnology · 2021Article
- A Mechanistic DNA Repair and Survival Model (Medras): Applications to Intrinsic Radiosensitivity, Relative Biological Effectiveness and Dose-Rate.Frontiers in oncology · 2021Article
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 3 countries.
Funding
Abstract
The cellular response to ionizing radiation continues to be of significant research interest in cancer radiotherapy, and DNA is recognized as the critical target for most of the biologic effects of radiation. Incident particles can cause initial DNA damages through physical and chemical interactions within a short time scale. Initial DNA damages can undergo repair via different pathways available at different stages of the cell cycle. The misrepair of DNA damage results in genomic rearrangement and causes mutations and chromosome aberrations, which are drivers of cell death. This work presents an integrated study of simulating cell response after proton irradiation with energies of 0.5-500 MeV (LET of 60-0.2 keV/µm). A model of a whole nucleus with fractal DNA geometry was implemented in TOPAS-nBio for initial DNA damage simulations. The default physics and chemistry models in TOPAS-nBio were used to describe interactions of primary particles, secondary particles, and radiolysis products within the nucleus. The initial DNA double-strand break (DSB) yield was found to increase from 6.5 DSB/Gy/Gbp at low-linear energy transfer (LET) of 0.2 keV/µm to 21.2 DSB/Gy/Gbp at high LET of 60 keV/µm. A mechanistic repair model was applied to predict the characteristics of DNA damage repair and dose response of chromosome aberrations. It was found that more than 95% of the DSBs are repaired within the first 24 h and the misrepaired DSB fraction increases rapidly with LET and reaches 15.8% at 60 keV/µm with an estimated chromosome aberration detection threshold of 3 Mbp. The dicentric and acentric fragment yields and the dose response of micronuclei formation after proton irradiation were calculated and compared with experimental results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.