Evidence map›Paper›PMID 32401606›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Effect of luminal flow on doming of mpkCCD cells in a 3D perfusable kidney cortical collecting duct model.

Joshua L Rein, Szilvia Heja, Daniel Flores, Rolando Carrisoza-Gaytán, Neil Y C Lin, Kimberly A Homan, Jennifer A Lewis, Lisa M Satlin

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Kidney Disease Modeling with Organoids and Organs-on-Chips.Annual review of biomedical engineering · 2024
    Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joshua L ReinDivision of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.
Szilvia HejaDivision of Pediatric Nephrology and Hypertension, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
Daniel FloresDivision of Pediatric Nephrology and Hypertension, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
Rolando Carrisoza-GaytánDivision of Pediatric Nephrology and Hypertension, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
Neil Y C LinSchool of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts.
Kimberly A HomanSchool of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts.
Jennifer A LewisSchool of Engineering and Applied Sciences, Wyss Institute for Biologically Inspired Engineering, Harvard University, Cambridge, Massachusetts.
Lisa M SatlinDivision of Pediatric Nephrology and Hypertension, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York.
Icahn School of Medicine at Mount Sinai · USHarvard University · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
The USC (Re)Building the Kidney Coordinating CenterU01DK107350 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KESSELMAN, CARL, VALERIUS, MICHAEL TODD · 2015 to 2019
$9.0M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
Mount Sinai Nephrology Research Training GrantT32DK007757 · NIDDK · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI CAMPBELL, KIRK N, HE, JOHN CIJIANG · 1998 to 2022
$3.8M
Vascularized kidney organoids on chip for efficacy and toxicity testing of somatic genome editingU01DK127587 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LEWIS, JENNIFER A., MORIZANE, RYUJI · 2020 to 2022
$2.1M
Kidney Microphysiological Analysis Platforms (MAP) to Optimize Function and Model DiseaseUG3TR002155 · NCATS · BRIGHAM AND WOMEN'S HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, LEE, LUKE P. · 2017 to 2018
$2.0M
Biomanufacturing of Vascularized Kidney Tissues: A Foundational Step towards Building a KidneyR56DK122380 · NIDDK · HARVARD UNIVERSITY · PI LEWIS, JENNIFER A. · 2019 to 2019
$530k
HHS | NIH | National Center for Advancing Translational Sciences (NCATS) UG3TR002155HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) P30DK079307HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01DK038470HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R56DK122380HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) T32DK007757HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) U01DK107350NCATS NIH HHS UG3 TR002155NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R56 DK122380NIDDK NIH HHS T32 DK007757NIDDK NIH HHS U01 DK127587
6 · The paper itself

Abstract

The cortical collecting duct (CCD) of the mammalian kidney plays a major role in the maintenance of total body electrolyte, acid/base, and fluid homeostasis by tubular reabsorption and excretion. The mammalian CCD is heterogeneous, composed of Na

Indexed as

Models, BiologicalPrinting, Three-DimensionalAnimalsBiological TransportCell Line, TransformedKidney Tubules, CollectingMiceMicroscopy, FluorescencePerfusion3D cortical collecting duct modelcell physiologyENaCfluid shear stressprincipal cell

Identifiers

PMID32401606
PMCPMC7468887
OpenAlexW3025608769

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.