Evidence map›Paper›PMID 32401602›Full record

ArticleAutophagy2021

CYBB/NOX2 in conventional DCs controls T cell encephalitogenicity during neuroinflammation.

Christian W Keller, Monika B Kotur, Sarah Mundt, Nikolaos Dokalis, Laure-Anne Ligeon, Ajay M Shah, Marco Prinz, Burkhard Becher, Christian Münz, Jan D Lünemann

Open access · greenAbstract read
In one paragraph

Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 97 citations in OpenAlex.

  1. Article
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  8. The Role of NADPH Oxidase 2 in Leukocytes.Antioxidants (Basel, Switzerland) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. CNS Resident Innate Immune Cells: Guardians of CNS Homeostasis.International journal of molecular sciences · 2024
    Review
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Autophagy pathways in autoimmune diseases.Journal of autoimmunity · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Christian W KellerDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0003-2276-0003
Monika B KoturLaboratory of Neuroinflammation, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Sarah MundtLaboratory of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.ORCID 0000-0003-2169-2109
Nikolaos DokalisInstitute of Neuropathology, Medical Faculty, University of Freiburg, Freiburg, Germany.
Laure-Anne LigeonLaboratory of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Ajay M ShahKing's College London British Heart Foundation Centre of Excellence, School of Cardiovascular Medicine & Sciences, London, UK.
Marco PrinzInstitute of Neuropathology, University of Freiburg; Signalling Research Centres BIOSS and CIBSS, Center for Basics in NeuroModulation (Neuromodulbasics), University of Freiburg, Freiburg, Germany.ORCID 0000-0002-0349-1955
Burkhard BecherLaboratory of Inflammation Research, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Christian MünzLaboratory of Viral Immunobiology, Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland.
Jan D LünemannDepartment of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.ORCID 0000-0002-3007-708X
University of Zurich · CHUniversity of Freiburg · DEKing's College London · GB

Funding

British Heart Foundation CH/1999001/11735British Heart Foundation RG/13/11/30384
6 · The paper itself

Abstract

Whereas central nervous system (CNS) homeostasis is highly dependent on tissue surveillance by immune cells, dysregulated entry of leukocytes during autoimmune neuroinflammation causes severe immunopathology and neurological deficits. To invade the CNS parenchyma, encephalitogenic T helper (T

Indexed as

AnimalsAutophagyDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalInflammationLymphocyte ActivationMacrophagesMyelin-Oligodendrocyte GlycoproteinNADPH Oxidase 2PhagocytosisT-LymphocytesCybb protein, mouseMyelin-Oligodendrocyte GlycoproteinNADPH Oxidase 2Antigen presentationautophagyCYBB/NOX2dendritic cellsexperimental autoimmune encephalomyelitisLC3-associated phagocytosismultiple sclerosis

Identifiers

PMID32401602
PMCPMC8143233
OpenAlexW3025964433

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.