Evidence map›Paper›PMID 32401601›Full record

ReviewCell cycle (Georgetown, Tex.)2020

Zooming in on chromosome dynamics.

John K Eykelenboom, Tomoyuki U Tanaka

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell cycle (Georgetown, Tex.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries.Biochimica et biophysica acta. Gene regulatory mechanisms · 2021
    Review
  3. FISH Going Meso-Scale: A Microscopic Search for Chromatin Domains.Frontiers in cell and developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

John K EykelenboomCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee , Dundee, UK.ORCID 0000-0003-4115-9686
Tomoyuki U TanakaCentre for Gene Regulation and Expression, School of Life Sciences, University of Dundee , Dundee, UK.ORCID 0000-0002-9886-5947
University of Dundee · GB

Funding

Biotechnology and Biological Sciences Research Council BB/S007768/1European Research Council 322682Wellcome TrustWellcome Trust 096535/Z/11/Z
6 · The paper itself

Abstract

Until recently, our understanding of chromosome organization in higher eukaryotic cells has been based on analyses of large-scale, low-resolution changes in chromosomes structure. More recently, CRISPR-Cas9 technologies have allowed us to "zoom in" and visualize specific chromosome regions in live cells so that we can begin to examine in detail the dynamics of chromosome organization in individual cells. In this review, we discuss traditional methods of chromosome locus visualization and look at how CRISPR-Cas9 gene-targeting methodologies have helped improve their application. We also describe recent developments of the CRISPR-Cas9 technology that enable visualization of specific chromosome regions without the requirement for complex genetic manipulation.

Indexed as

AnimalsCell SurvivalChromosomesCRISPR-Associated Protein 9CRISPR-Cas SystemsGenetic LociHumansCRISPR-Associated Protein 9chromosome dynamicsChromosome structureCRISPR-Cas9 technologyfluorescent visualizationlive-cell imaging

Identifiers

PMID32401601
PMCPMC7480819
OpenAlexW3024727996

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.