ArticleThe American journal of clinical nutrition2020
Genetic susceptibility, plant-based dietary patterns, and risk of cardiovascular disease.
Article in The American journal of clinical nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 7 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 7 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Pooled it
- Pooled it
- Gene-diet interactions and cardiovascular diseases: a systematic review of observational and clinical trials.BMC cardiovascular disorders · 2022Pooled it
- Pooled it
- Risk of Incident Stroke among Vegetarians Compared to Nonvegetarians: A Systematic Review and Meta-Analysis of Prospective Cohort Studies.Nutrients · 2021Pooled it
- Pooled it
- The Association of Plant-Based Diet With Cardiovascular Disease and Mortality: A Meta-Analysis and Systematic Review of Prospect Cohort Studies.Frontiers in cardiovascular medicine · 2021Pooled it
- Impact of a whole food, plant-based diet on LDL-cholesterol and cardiovascular risk factors in adults with heterozygous familial hypercholesterolemia: a randomized, two-period, two-treatment, crossover, fully controlled feeding trial.Nature communications · 2026Trial
- Planetary health diet index and risk of irritable bowel syndrome: a prospective cohort study.European journal of nutrition · 2026Article
- Association of Dietary Patterns and Genetic Risk With Cardiovascular Disease in UK Biobank Cancer Survivors.Journal of the American Heart Association · 2026Article
- Plant-based diet quality, fat mass, and cardiovascular disease: A mediation analysis of mid-aged adults in the UK Biobank.European journal of clinical nutrition · 2026Article
- A narrative review of dietary patterns in cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2026Review
- A hypothetical intervention analysis for the effects of healthy dietary patterns on reducing major chronic diseases and mortality associated with air pollutant mixtures.BMC medicine · 2025Article
- Trajectories of plant-based dietary patterns and their sex-specific associations with cardiometabolic health among young Australian adults.The international journal of behavioral nutrition and physical activity · 2025Article
- Response to "Letter to the editor on: Unhealthful plant-based diet associates with frailty risk predominantly in men with low income from the UK Biobank cohort".The journal of nutrition, health & aging · 2025Article
- Article
- Association of plant-based diet indexes with the metabolomic profile.Scientific reports · 2024Article
- A plant-based diet index to study the relation between diet and disease risk among adults: a narrative review.The journal of nutrition, health & aging · 2024Review
- Article
- Association of plant-based diets with total and cause-specific mortality across socioeconomic deprivation level: a large prospective cohort.European journal of nutrition · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPlant-based dietary patterns may be related to better cardiovascular profiles. Whether a healthy plant-based dietary index is predictive of future cardiovascular disease (CVD) across people with different genetic susceptibility remains uncertain.
objectiveWe investigated associations of adherence to healthy plant-based diets with the incidence of CVD considering the genetic susceptibility.
methodsThis prospective cohort study included a total of 156,148 adults initially free of CVD and cancer. We calculated a healthful plant-based diet index (healthful-PDI) in which healthy plant foods received positive scores, and less healthy plant foods and animal foods received reverse scores. Genetic risk scores (GRSs) for myocardial infarction (MI) and stroke were calculated to assess interactions between healthful-PDI and GRSs.
resultsDuring 5 y of follow-up, we observed 1812 incident cases of CVD. Higher healthful-PDI was associated with a lower CVD risk [HR per 10-unit increment: 0.87 (95% CI: 0.81, 0.93) after adjusting for demographic, lifestyle, and other dietary factors (model 1); HR 0.90 (0.84, 0.97) after further adjusting for obesity and metabolic factors (model 2)]. The risk of CVD was gradually decreased in association with higher adherence to healthful-PDI, regardless of genetic susceptibility. The inverse associations of healthful-PDI with CVD were consistently observed in people with low GRS-MI [HR 0.85 (95% CI: 0.76, 0.94) in model 1; HR 0.88 (0.79, 0.97) in model 2] and those with high GRS-MI [HR 0.91 (0.82, 0.99) in model 1; HR 0.94 (0.86, 1.04) in model 2], without significant interactions (Pinteraction = 0.59 in model 1; Pinteraction = 0.66 in model 2). Similarly, higher healthful-PDI was related to a lower risk of CVD, regardless of low/high GRS-stroke.
conclusionAdherence to healthy plant-based diets may be associated with a decreased incidence of CVD in the entire population, suggesting that plant-based dietary patterns may modify the risk of CVD, regardless of genetic susceptibility.
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