Evidence map›Paper›PMID 32401197›Full record

ArticleeLife2020

Spontaneous and evoked neurotransmission are partially segregated at inhibitory synapses.

Patricia M Horvath, Michelle K Piazza, Lisa M Monteggia, Ege T Kavalali

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 38 citations in OpenAlex.

  1. Lithium as a therapeutic strategy for SNAP25 encephalopathies via modulation of homeostatic plasticity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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  8. Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Opioid Receptors Modulate Inhibition within the Prefrontal Cortex through Dissociable Cellular and Molecular Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  10. Prefrontal cortex excitatory neurons show distinct response to heroin-associated cue and social stimulus after prolonged heroin abstinence in mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  11. Article
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  14. WWC2 modulates GABACell reports · 2024
    Article
  15. MDGAs perform activity-dependent synapse type-specific suppression via distinct extracellular mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
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  20. Rapid homeostatic plasticity and neuropsychiatric therapeutics.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patricia M HorvathDepartment of Pharmacology, Vanderbilt University, Nashville, United States.ORCID 0000-0001-9969-8637
Michelle K PiazzaVanderbilt Brain Institute, Vanderbilt University, Nashville, United States.ORCID 0000-0002-7852-3456
Lisa M MonteggiaDepartment of Pharmacology, Vanderbilt University, Nashville, United States.ORCID 0000-0003-0018-501X
Ege T KavalaliDepartment of Pharmacology, Vanderbilt University, Nashville, United States.ORCID 0000-0003-1777-227X
Vanderbilt University · US

Funding

ANTIDEPRESSANTS & INTRACELLULAR SIGNALING LINKED TO BDNFR01MH070727 · NIMH · VANDERBILT UNIVERSITY · PI LISA M MONTEGGIA · 2005 to 2026
$8.9M
Role of SNARE Interactions in Central Synapse FunctionR01MH066198 · NIMH · VANDERBILT UNIVERSITY · PI KAVALALI, EGE T · 2004 to 2023
$7.9M
Training in Fundamental NeuroscienceT32MH064913 · NIMH · VANDERBILT UNIVERSITY · PI IHRIE, REBECCA A, WINDER, DANNY G. · 2001 to 2022
$7.6M
Research Project: Sensory and Multisensory Contributions to AutismU54HD083211 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DYKENS, ELISABETH MAY · 2015 to 2019
$7.1M
DIVISION OF CELL &MOLECULAR BIOLOGY TRAINING PROGRAMT32GM008203 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI COBB, MELANIE H. · 1987 to 2018
$7.0M
MECP2 DEPENDENT TRANSCRIPTIONAL REPRESSION & NEUROTRANSMISSIONR01MH081060 · NIMH · VANDERBILT UNIVERSITY · PI MONTEGGIA, LISA M · 2008 to 2017
$3.7M
NICHD NIH HHS U54 HD083211NIGMS NIH HHS T32 GM008203NIMH NIH HHS R01 MH066198NIMH NIH HHS R01 MH070727NIMH NIH HHS R01 MH081060NIMH NIH HHS R01 MH66198NIMH NIH HHS T32 MH064913
6 · The paper itself

Abstract

Synaptic transmission is initiated via spontaneous or action-potential evoked fusion of synaptic vesicles. At excitatory synapses, glutamatergic receptors activated by spontaneous and evoked neurotransmission are segregated. Although inhibitory synapses also transmit signals spontaneously or in response to action potentials, they differ from excitatory synapses in both structure and function. Therefore, we hypothesized that inhibitory synapses may have different organizing principles. We report picrotoxin, a GABA

Indexed as

Inhibitory Postsynaptic PotentialsNeural InhibitionSynaptic TransmissionAnimalsCells, CulturedElectric StimulationFemaleGABA AntagonistsGABAergic NeuronsHippocampusIn Vitro TechniquesPicrotoxinRats, Sprague-DawleyReceptors, GABA-AGABA AntagonistsPicrotoxinReceptors, GABA-AGABAergic neurotransmissionneurosciencepicrotoxinratspontaneous release

Identifiers

PMID32401197
PMCPMC7250572
OpenAlexW3024350361

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.