Evidence map›Paper›PMID 32401194›Full record

ArticleeLife2020

Synergistic roles of Synaptotagmin-1 and complexin in calcium-regulated neuronal exocytosis.

Sathish Ramakrishnan, Manindra Bera, Jeff Coleman, James E Rothman, Shyam S Krishnakumar

Abstract readVideo-Audio Media
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  18. Dynamic Formation of the Protein-Lipid Pre-fusion Complex.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Synaptophysin chaperones the assembly of 12 SNAREpins under each ready-release vesicle.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sathish RamakrishnanDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0002-7844-2234
Manindra BeraDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-9297-8126
Jeff ColemanDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.
James E RothmanDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-8653-8650
Shyam S KrishnakumarDepartment of Cell Biology, Yale University School of Medicine, New Haven, United States.ORCID 0000-0001-6148-3251

Funding

Regulation of Membrane Fusion in ExocytosisR01DK027044 · NIDDK · YALE UNIVERSITY · PI KRISHNAKUMAR, SHYAM S · 1986 to 2021
$8.2M
MECHANISMS OF INTRACELLULAR MEMBRANE FUSIONR37DK027044 · NIDDK · YALE UNIVERSITY · PI ROTHMAN, JAMES · 1992 to 2012
$5.3M
NIDDK NIH HHS 027044NIDDK NIH HHS R01 DK027044NIDDK NIH HHS R37 DK027044
6 · The paper itself

Abstract

Calcium (Ca

Indexed as

Calcium SignalingExocytosisAdaptor Proteins, Vesicular TransportAnimalsCalciumHumansKineticsLiposomesMembrane FusionMiceMutationNerve Tissue ProteinsRatsSNARE ProteinsSynaptic VesiclesSynaptotagmin IAdaptor Proteins, Vesicular TransportCalciumcomplexin ILiposomesNerve Tissue ProteinsSNARE ProteinsSynaptotagmin ISyt1 protein, ratVesicle-Associated Membrane Protein 2calciumcomplexinE. colimolecular biophysicsneurotransmissionstructural biologysynaptotagminvesicle fusion

Identifiers

PMID32401194
PMCPMC7220375

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.