Evidence map›Paper›PMID 32401145›Full record

ArticleJournal of neurophysiology2020

The serotonin reuptake blocker citalopram destabilizes fictive locomotor activity in salamander axial circuits through 5-HT

Aurélie Flaive, Jean-Marie Cabelguen, Dimitri Ryczko

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Investigation of central pattern generators in the spinal cord of chicken embryos.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Aurélie FlaiveDépartement de Pharmacologie-Physiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada.
Jean-Marie CabelguenNeurocentre Magendie, INSERM U 862, Université de Bordeaux, Bordeaux Cedex, France.
Dimitri RyczkoDépartement de Pharmacologie-Physiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, Sherbrooke, Quebec, Canada.ORCID 0000-0003-3948-7728
Centre Hospitalier Universitaire de Sherbrooke · CAInserm · FRUniversité de Sherbrooke · CA

Funding

CIHR 407083
6 · The paper itself

Abstract

Serotoninergic (5-HT) neurons are powerful modulators of spinal locomotor circuits. Most studies on 5-HT modulation focused on the effect of exogenous 5-HT and these studies provided key information about the cellular mechanisms involved. Less is known about the effects of increased release of endogenous 5-HT with selective serotonin reuptake inhibitors. In mammals, such molecules were shown to destabilize the fictive locomotor output of spinal limb networks through 5-HT

Indexed as

Ambystoma mexicanumAnimalsBehavior, AnimalCaudataCitalopramInterneuronsLocomotionMotor NeuronsNerve NetReceptor, Serotonin, 5-HT1ASalamandridaeSelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor AntagonistsSpinal Nerve RootsCitalopramReceptor, Serotonin, 5-HT1ASelective Serotonin Reuptake InhibitorsSerotonin 5-HT1 Receptor AgonistsSerotonin 5-HT1 Receptor Antagonists5-HT1Acitalopramlocomotionsalamanderserotonin

Identifiers

PMID32401145
PMCPMC7311723
OpenAlexW3024162783

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.