Evidence map›Paper›PMID 32400967›Full record

Observational studyESC heart failure2020

Left bundle branch area pacing delivery of cardiac resynchronization therapy and comparison with biventricular pacing.

Xiaofei Li, Chunguang Qiu, Ruiqin Xie, Wentao Ma, Zhao Wang, Hui Li, Hao Wang, Wei Hua, Shu Zhang, Yan Yao and 1 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 68 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 12 pooled it
14.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04624763 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

Protection on Cardiac Function With Left Bundle Branch Pacing in Patients With Atrioventricular Block(OptimPacing)

TypeinterventionalSponsorThe First Affiliated Hospital with Nanjing Medical UniversityRan2021 to 2028Enrolled683ConditionsAtrioventricular BlockArmsLeft bundle branch pacing, Right ventricular pacing
NCT04730921 nacompletednot on this map

Impact of Left Bundle Branch Area Pacing vs. Right Ventricular Pacing in Atrioventricular Block (LEAP-Block): A Randomized Controlled Trial

TypeinterventionalSponsorFu Wai Hospital, Beijing, ChinaRan2020 to 2025Enrolled486ConditionsAtrioventricular Block, Left Bundle Branch Area Pacing, Right Ventricular Pacing, Heart FailureArmsLeft bundle branch area pacing, Right ventricular pacing
3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 12 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Conduction system pacing vs. biventricular pacing for cardiac resynchronization therapy in heart failure: a systematic review and meta-analysis considering randomized controlled trials and observational studies.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026
    Pooled it
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  3. Outcomes of Left Bundle Branch Area Pacing in Heart Failure Patients: A Systematic Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026
    Pooled it
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  5. Improved all-cause mortality with left bundle branch area pacing compared to biventricular pacing in cardiac resynchronization therapy: a meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024
    Pooled it
  6. Pooled it
  7. Guideline
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  11. Pooled it
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  13. Trial
  14. Review
  15. Article
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  18. Left Bundle Branch Pacing Improved the Outcome of End-Stage Hypertrophic Cardiomyopathy: A Case Report.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2025
    Article
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xiaofei LiState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Chunguang QiuDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University, 1 Jianshe E Rd, Erqi District, Zhengzhou, Henan, China.
Ruiqin XieDepartment of Cardiology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Wentao MaState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Zhao WangState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Hui LiDepartment of Echocardiography, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Hao WangDepartment of Echocardiography, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Wei HuaState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Shu ZhangState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Yan YaoState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.
Xiaohan FanState Key Laboratory of Cardiovascular Disease, Cardiac Arrhythmia Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167 Beilishi Road, Xicheng, Beijing, China.ORCID 0000-0003-2325-3839
Chinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Zhengzhou University · CNHebei Medical University · CN

Funding

National Natural Science Foundation of China 81970284
6 · The paper itself

Abstract

aimsThis multicentre observational study aimed to prospectively assess the efficacy of left bundle branch area pacing (LBBAP) in heart failure patients with left bundle branch block (LBBB) and compare the 6-month outcomes between LBBAP and biventricular pacing (BVP). METHODS AND

resultsConsecutive patients with LBBB and left ventricular ejection fraction (LVEF) ≤ 35% were prospectively recruited if they had undergone LBBAP as a primary or rescue strategy from three separate centres from March to December 2018. Patients who received BVP in 2018 were retrospectively selected by using 2 to 1 propensity score matching to minimize bias. Implant characteristics and echocardiographic parameters were assessed during the 6-month follow-up. LBBAP procedure succeeded in 81.1% (30/37) of patients, with selective LBBAP in 10 patients, and 3 of 20 patients combined non-selective LBBAP and LV lead pacing for further QRS narrowing. LBBAP resulted in significant QRS narrowing (from 178.2 ± 18.8 to 121.8 ± 10.8 ms, P < 0.001, paced QRS duration ≤ 130 ms in 27 patients) and improved LVEF (from 28.8 ± 4.5% to 44.3 ± 8.7%, P < 0.001) during the 6-month follow-up. The comparison between 27 patients with LBBAP alone and 54 of 130 matching patients with BVP showed that LBBAP delivered a greater reduction in the QRSd (58.0 vs. 12.5 ms, P < 0.001), a greater increase in LVEF (15.6% vs. 7.0%, P < 0.001), and greater echocardiographic (88.9% vs. 66.7%, P = 0.035) and super response (44.4% vs. 16.7%, P = 0.007) to cardiac resynchronization therapy.

conclusionsLBBAP could deliver cardiac resynchronization therapy in most patients with heart failure and LBBB, and might be a promising alternative resynchronization approach to BVP.

Indexed as

Cardiac Resynchronization TherapyElectrocardiographyHumansRetrospective StudiesStroke VolumeTreatment OutcomeVentricular Function, LeftCardiac resynchronization therapyHeart failureLeft bundle branch area pacingLeft bundle branch block

Identifiers

PMID32400967
PMCPMC7373885
OpenAlexW3024505753

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.