Evidence map›Paper›PMID 32400901›Full record

ArticleInternational journal of geriatric psychiatry2020

The 5-HTTLPR long allele predicts two-year longitudinal increases in cortisol and declines in verbal memory in older adults.

Rayna B Hirst, Joshua T Jordan, Sophia Miryam Schüssler-Fiorenza Rose, Logan Schneider, Makoto Kawai, Christine E Gould, Lauren Anker, Christina F Chick, Sherry A Beaudreau, Joachim Hallmayer and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of geriatric psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Rayna B HirstDepartment of Psychology, Palo Alto University, Palo Alto, CA, USA.ORCID 0000-0001-5586-9641
Joshua T JordanDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Sophia Miryam Schüssler-Fiorenza RoseDepartment of Genetics, Stanford University, Stanford, CA, USA.ORCID 0000-0002-6311-6671
Logan SchneiderDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8729-5224
Makoto KawaiDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Christine E GouldDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8901-2363
Lauren AnkerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Christina F ChickDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Sherry A BeaudreauDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9853-9332
Joachim HallmayerDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
Ruth O'HaraDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.
VA Palo Alto Health Care System · USPalo Alto University · USStanford University · USUniversity of California, San Francisco · US

Funding

Stress, The HPA and Health in AgingP01AG018784 · NIA · STANFORD UNIVERSITY · PI SPIEGEL, DAVID · 2001 to 2008
$8.7M
STANFORD ALZHEIMER'S DISEASE CORE CENTERP30AG017824 · NIA · STANFORD UNIVERSITY · PI YESAVAGE, JEROME A · 2000 to 2005
$5.3M
MCI, APOE and Sleep Apnea: Effects on CognitionR01MH070886 · NIMH · STANFORD UNIVERSITY · PI O'HARA, RUTH M · 2005 to 2009
$1.4M
Cortical Hemodynamism and Oxygenation During Sleep and Cognition: Window to Cognitive Impairment and Neurodegeneration in AgingK23AG053465 · NIA · STANFORD UNIVERSITY · PI KAWAI, MAKOTO · 2017 to 2022
$1.1M
Integrating the Exposome into Longitudinal Multiomics ProfilingK08ES028825 · NIEHS · STANFORD UNIVERSITY · PI ROSE, SOPHIA MIRYAM SCHÜSSLER-FIORENZA · 2018 to 2022
$1.0M
Reducing Anxiety and Improving Functioning in Older VeteransIK2RX001478 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI GOULD, CHRISTINE E. · 2015 to 2020
–
NIA NIH HHS K23 AG053465NIA NIH HHS P01 AG018784NIA NIH HHS P30 AG017824NIEHS NIH HHS K08 ES028825NIMH NIH HHS R01 MH070886RRD VA IK2 RX001478
6 · The paper itself

Abstract

objectivesThe short form or s-allele variant of the serotonin transporter polymorphism (5-HTTLPR), as compared with the long-form or l-allele variant, has been associated with the presence of cognitive dysfunction, and particularly memory impairment in older adults. This body of cross-sectional work has culminated in the hypothesis that presence of the s-allele predicts greater memory decline in older adults. Yet, to date, there are no longitudinal studies that have investigated this issue. METHODS/

designHere, we examine 109 community-dwelling older adults (mean and SD of age = 70.7 ± 8.7 years) who underwent blood draw for genotyping, cognitive, and psychological testing at baseline, 12-, and 24-monthfollow-ups.

resultsMultilevel modeling found that s-allele carriers (ss or ls) performed worse than ll homozygotes at baseline on delayed verbal recall. Yet, s-allele carriers' memory performance was stable over the two-yearfollow-up period, while l-allele homozygotes experienced significant memory decline. l-allele homozygote status was associated with both increased cortisol and decreased memory over time, resulting in attenuated verbal memory performance differences compared to s-allele carriers with age.

conclusionsOverall, our findings do not support the hypothesis that presence of the 5-HTTLPRs-allele is a marker for memory decline in older adults. J Am Geriatr Soc 68:-, 2020.

Indexed as

HydrocortisoneSerotonin Plasma Membrane Transport ProteinsAgedAllelesCross-Sectional StudiesGenotypeHumansHydrocortisoneSerotonin Plasma Membrane Transport Proteinscortisollongitudinalmemoryolder adultsserotonin transporter

Identifiers

PMID32400901
PMCPMC7755300
OpenAlexW3025356894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.