Evidence map›Paper›PMID 32400390›Full record

ArticleeLife2020

Dissecting the phenotypic and functional heterogeneity of mouse inflammatory osteoclasts by the expression of

Maria-Bernadette Madel, Lidia Ibáñez, Thomas Ciucci, Julia Halper, Matthieu Rouleau, Antoine Boutin, Christophe Hue, Isabelle Duroux-Richard, Florence Apparailly, Henri-Jean Garchon and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
3.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

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  12. Innate immune memory in inflammatory arthritis.Nature reviews. Rheumatology · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Origin of Osteoclasts: Osteoclast Precursor Cells.Journal of bone metabolism · 2023
    Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Maria-Bernadette MadelLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.
Lidia IbáñezDepartment of Pharmacy, Cardenal Herrera-CEU University, Valencia, Spain.
Thomas CiucciLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, United States.
Julia HalperLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.
Matthieu RouleauLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.ORCID 0000-0002-0075-9880
Antoine BoutinLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.
Christophe HueUniversité Paris-Saclay, UVSQ, INSERM, Infection et inflammation, Montigny-Le-Bretonneux, France.
Isabelle Duroux-RichardIRMB, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Florence ApparaillyIRMB, Univ Montpellier, INSERM, CHU Montpellier, Montpellier, France.
Henri-Jean GarchonUniversité Paris-Saclay, UVSQ, INSERM, Infection et inflammation, Montigny-Le-Bretonneux, France.
Abdelilah WakkachLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.
Claudine Blin-WakkachLaboratoire de PhysioMédecine Moléculaire, CNRS, Nice, France.ORCID 0000-0002-2621-3907
Centre National de la Recherche Scientifique · FRInserm · FRNational Institutes of Health · USUniversidad Cardenal Herrera CEU · ES

Funding

Agence Nationale de la Recherche ANR-15-IDEX-01Agence Nationale de la Recherche ANR-16-CE14-0030Fondation pour la Recherche Médicale ECO20160736019
6 · The paper itself

Abstract

Bone destruction relies on interactions between bone and immune cells. Bone-resorbing osteoclasts (OCLs) were recently identified as innate immune cells activating T cells toward tolerance or inflammation. Thus, pathological bone destruction not only relies on increased osteoclast differentiation, but also on the presence of inflammatory OCLs (i-OCLs), part of which express

Indexed as

OsteogenesisAnimalsBone ResorptionCell CommunicationCells, CulturedCX3C Chemokine Receptor 1FemaleInflammationMice, Inbred C57BLMice, KnockoutOsteoclastsOsteoporosisOvariectomyPhenotypeSignal TransductionT-Lymphocytes, RegulatoryCX3C Chemokine Receptor 1Cx3cr1 protein, mouseTnf protein, mouseTumor Necrosis Factor-alphabone destructioncell biologyimmunologyinflammationmouseosteoclastosteoimmunologyosteoporosis

Identifiers

PMID32400390
PMCPMC7220377
OpenAlexW3024041874

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.