Evidence map›Paper›PMID 32400129›Full record

ArticleAllergy, asthma & immunology research2020

Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid.

Min Gyu Kang, Hyun Seung Lee, Kelan G Tantisira, Heung Woo Park

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Min Gyu KangDepartment of Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea.ORCID https://orcid.org/0000-0002-3239-4492
Hyun Seung LeeInstitute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-4599-8527
Kelan G TantisiraThe Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0003-2950-3384
Heung Woo ParkInstitute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-6970-3228
Brigham and Women's Hospital · USChungbuk National University Hospital · KRSeoul National University Hospital · KR

Funding

THE PHARMACOGENETICS OF ASTHMA TREATMENTU01HL065899 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G, WEISS, SCOTT T · 2000 to 2014
$38.5M
INTEGRATIVE PHARMACOGENOMICS OF LEUKOTRIENE INHIBITION IN ASTHMAR01HL092197 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2009 to 2013
$3.6M
GENOMICS AND PHARMACOGENOMICS OF SYMPTOMS IN ASTHMAR01NR013391 · NINR · BRIGHAM AND WOMEN'S HOSPITAL · PI TANTISIRA, KELAN G · 2011 to 2013
$1.3M
NHLBI NIH HHS R01 HL092197NHLBI NIH HHS U01 HL065899NIH HHS R01 HL092197NIH HHS R01 NR13391NIH HHS U01 HL065899NINR NIH HHS R01 NR013391Seoul National University Hospital 0320140400 (2014-1194)
6 · The paper itself

Abstract

purposeAcute exacerbation (AE) is an important domain of asthma management and may be related with ineffective response to corticosteroid. This study aimed to find mechanisms of AE using genome-wide gene expression profiles of blood cells from asthmatics and its perturbation by

methodsWe utilized lymphoblastoid B cells from 107 childhood asthmatics and peripheral blood mononuclear cells from 29 adult asthmatics who were treated with inhaled corticosteroids. We searched for a preserved co-expression gene module significantly associated with the AE rate in both cohorts and measured expression changes of genes belong to this module after Dex-treatment.

resultsWe identified a preserved module composed of 77 genes. Among them, expressions of 2 genes (

conclusionsMany genes belong to the AE rate-associated and preserved module identified in blood cells from childhood and adults asthmatics showed no expression changes after

Indexed as

Asthmabloodgene expressionsteroidssymptom flare up

Identifiers

PMID32400129
PMCPMC7224997
OpenAlexW3014306692

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.