ArticleAging cell2020
Glutathione peroxidase-1 overexpression reduces oxidative stress, and improves pathology and proteome remodeling in the kidneys of old mice.
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Article in Aging cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25citing papers in PubMed
12.4field-weighted citation impact, top 1% of its field
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Who cites it
25 citing papers in PubMed, 61 citations in OpenAlex.
- On the Edge of Benefit and Harm: Reactive Oxygen Species in Cancer.International journal of molecular sciences · 2026Review
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- The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.Aging cell · 2026Article
- The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney.bioRxiv : the preprint server for biology · 2026Article
- Article
- Scavenging of reactive oxygen and nitrogen species using nanoparticles and their applications in disease management.RSC advances · 2025Review
- Regulation of stem cell aging and cellular proliferation by Klotho-Sirt1 pathways in heart, kidney and small intestine.npj aging · 2025Article
- The effectiveness of antioxidant agents in delaying progression of diabetic nephropathy: A systematic review of randomized controlled trials.BioImpacts : BI · 2025Review
- Selenium nanoparticles ameliorate lumbar disc degeneration by restoring GPX1-mediated redox homeostasis and mitochondrial function of nucleus pulposus cells.Journal of nanobiotechnology · 2024Article
- Interplay between the Redox System and Renal Tubular Transport.Antioxidants (Basel, Switzerland) · 2024Review
- Molecular Mechanisms Associated with Aging Kidneys and Future Perspectives.International journal of molecular sciences · 2023Review
- New Dawn for Atherosclerosis: Vascular Endothelial Cell Senescence and Death.International journal of molecular sciences · 2023Review
- Review
- Mountain-cultivated ginseng protects against cognitive impairments in aged GPx-1 knockout mice via activation of Nrf2/ChAT/ERK signaling pathway.Journal of ginseng research · 2023Article
- Selenoproteins and the senescence-associated epitranscriptome.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development.Trends in cell biology · 2022Review
- The Effects of a Meldonium Pre-Treatment on the Course of the LPS-Induced Sepsis in Rats.International journal of molecular sciences · 2022Article
- Cholesterol Metabolism in Chronic Kidney Disease: Physiology, Pathologic Mechanisms, and Treatment.Advances in experimental medicine and biology · 2022Article
- Inflammation and Cardiovascular Disease Associated With Hemodialysis for End-Stage Renal Disease.Frontiers in pharmacology · 2022Review
- Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants.Communications biology · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Yi ChuDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Renny S LanProteomics Core, Department of Biochemistry and Molecular Biology, University of Arkansas Medical Sciences College of Medicine, Little Rock, Arkansas.
Rui HuangDepartment of Statistics and Actuarial Science, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa.
Hao FengDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Rahul KumarDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Sanjana DayalDepartment of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa.
Kung-Sik ChanDepartment of Statistics and Actuarial Science, College of Liberal Arts and Sciences, University of Iowa, Iowa City, Iowa.
Dao-Fu DaiDepartment of Pathology, Carver College of Medicine, University of Iowa, Iowa City, Iowa.ORCID 0000-0001-7724-321X
University of Iowa · USUniversity of Arkansas Medical Center · US
Funding
Translational Regulation in Normal Erythropoiesis and Diamond Blackfan AnemiaP20GM121293 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI Alan Tackett, Sean D. Taverna · 2017 to 2026
$27.6MTargeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9MPreventive mechanisms of Age-associated ThrombosisR01HL168630 · NHLBI · UNIVERSITY OF IOWA · PI Sanjana Dayal · 2024 to 2026
$1.8MPeroxide mediated prothrombotic effects of aging (Supplement)R01AG049784 · NIA · UNIVERSITY OF IOWA · PI DAYAL, SANJANA · 2015 to 2019
$1.8MThe role of energy sensor signaling in mitochondrial cardiomyopathyK08HL145138 · NHLBI · UNIVERSITY OF IOWA · PI DAI, DAO-FU · 2019 to 2023
$803kNHLBI NIH HHS K08 HL145138NHLBI NIH HHS R01 HL168630NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG049784NIGMS NIH HHS P20 GM121293
Abstract
This study investigated the direct roles of hydrogen peroxide (H
Indexed as
Age FactorsAnimalsGlutathione PeroxidaseGlutathione Peroxidase GPX1KidneyMiceMice, TransgenicOxidative StressProteomeProteomicsReactive Oxygen SpeciesGlutathione PeroxidaseGlutathione Peroxidase GPX1Gpx1 protein, mouseProteomeReactive Oxygen Speciesglutathione peroxidase-1kidney agingmitochondriaproteomicsreactive oxygen species
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.