ArticleNeurochemical research2020
The Reducible Disulfide Proteome of Synaptosomes Supports a Role for Reversible Oxidations of Protein Thiols in the Maintenance of Neuronal Redox Homeostasis.
Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins.Scientific reports · 2025Article
- Protein vicinal thiols as intrinsic probes of brain redox states in health, aging, and ischemia.Metabolic brain disease · 2024Article
- Recent progress in analytical strategies of arsenic-binding proteomes in living systems.Analytical and bioanalytical chemistry · 2023Review
- Ecstasy metabolites and monoamine neurotransmitters upshift the NaArchives of toxicology · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms by which neurons maintain redox homeostasis, disruption of which is linked to disease, are not well known. Hydrogen peroxide, a major cellular oxidant and neuromodulator, can promote reversible oxidations of protein thiols but the scope, targets, and significance of such oxidations occurring in neurons, especially in vivo, are uncertain. Using redox phenylarsine oxide (PAO)-affinity chromatography, which exploits the high-affinity of trivalent arsenicals for protein dithiols, this study investigated the occurrence of reducible and, therefore, potentially regulatory, protein disulfide bonds in Triton X-100-soluble protein fractions from isolated nerve-endings (synaptosomes) prepared from rat brains. Postmortem oxidations of protein thiols were limited by rapidly freezing the brains following euthanasia and, later, homogenizing them in the presence of the N-ethylmaleimide to trap reduced thiols. The reducible disulfide proteome comprised 5.4% of the total synaptosomal protein applied to the immobilized PAO columns and was overrepresented by pathways underlying ATP synaptic supply and demand including synaptic vesicle trafficking. The alpha subunits of plasma membrane Na
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