Evidence map›Paper›PMID 32399735›Full record

SynthesisClinical oral investigations2020

Ineffectiveness of ozone therapy in nonsurgical periodontal treatment: a systematic review and metaanalysis of randomized clinical trials.

Vittorio Moraschini, Ingrid Chaves Cavalcante Kischinhevsky, Monica Diuana Calasans-Maia, Jamil Awad Shibli, Suelen Cristina Sartoretto, Carlos Marcelo Figueredo, José Mauro Granjeiro

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 4 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 4 syntheses or guidelines pooled it, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Vittorio MoraschiniDepartment of Periodontology, Dental Research Division, School of Dentistry, Veiga de Almeida University, Rua Ibituruna, 108, Maracanã, Rio de Janeiro, Brazil. vitt.mf@gmail.com.
Ingrid Chaves Cavalcante KischinhevskyDepartment of Oral Surgery, Dentistry School, Fluminense Federal University, Rua Mario dos Santos Braga, 30, Centro, Niterói, Rio de Janeiro, 24020-140, Brazil.
Monica Diuana Calasans-MaiaDepartment of Oral Surgery, Dentistry School, Fluminense Federal University, Rua Mario dos Santos Braga, 30, Centro, Niterói, Rio de Janeiro, 24020-140, Brazil.
Jamil Awad ShibliDepartment of Periodontology and Oral Implantology, Dental Research Division, University of Guarulhos, São Paulo, Brazil.
Suelen Cristina SartorettoDepartment of Periodontology, Dental Research Division, School of Dentistry, Veiga de Almeida University, Rua Ibituruna, 108, Maracanã, Rio de Janeiro, Brazil.
Carlos Marcelo FigueredoDepartment of Periodontology, Faculty of Dentistry and Oral Health, Griffith University, Brisbane, Queensland, Australia.
José Mauro GranjeiroDepartment of Dental Technics, School of Dentistry, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.
Universidade Federal Fluminense · BRUniversidade Veiga de Almeida · BRGriffith University · AUGuarulhos University · BRInstituto Nacional de Metrologia, Qualidade e Tecnologia · BR

Funding

Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro 202619/17
6 · The paper itself

Abstract

objectiveThis systematic review (SR) aimed at assessing the adjunctive clinical effect of ozone therapy (OT) on nonsurgical periodontal treatment. MATERIALS AND

methodsArticles published prior to September 2019 were electronically searched in four databases without any other date or language restrictions and manually searched in regular journals and in gray literature. This review was performed according to the PICO format. The eligibility criteria comprised randomized controlled trials (RCTs) that analyzed the adjunctive effect of OT on nonsurgical periodontal treatment.

resultsTwelve studies published between 2010 and 2019 were included in this SR. A metaanalysis of ten reports showed that there was no statistically significant difference in the periodontal parameters analyzed when scaling and root planing (SRP) plus sulcus irrigation with ozonated water or sulcus insertion of ozonated gas were used when compared to SRP alone. Additionally, there was no significant difference when the effect of SRP plus ozonated water was compared with SRP plus 2% chlorhexidine gluconate (CLX). No studies reported significant microbiological differences when the use of ozone was compared with SRP alone.

conclusionsThe results of this SR do not support the use of OT for nonsurgical periodontal treatment. However, due to the potential heterogeneity across the studies, the presence of confounding factors, and the short follow-up of some included RCTs, these results should not be considered definitive. CLINICAL RELEVANCE: The current evidence indicates that ozone has antimicrobial activity and good biocompatibility with periodontal cells and gingival fibroblasts. However, no evidence was found for a positive effect of OT as an adjunct to scaling and root planing.

Indexed as

Chronic PeriodontitisOzoneRoot PlaningCombined Modality TherapyDental ScalingRandomized Controlled Trials as TopicOzoneOzonePeriodontal diseasePeriodontal treatmentSystematic review

Identifiers

PMID32399735
OpenAlexW3024272416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.