Evidence map›Paper›PMID 32399727›Full record

Observational studyNeurosurgical review2021

Pulmonary embolism in neurocritical care-introduction of a novel grading system for risk stratification: the Frankfurt AMBOS score.

Daniel Dubinski, Fee Keil, Sae-Yeon Won, Bedjan Behmanesh, Kolja Jahnke, Volker Seifert, Christof Geisen, Juergen Konczalla, Christian Senft

Open access · hybridAbstract readObservational Study
In one paragraph

Observational study in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Tumor treating fields alter local coagulation dynamics in glioblastoma patients.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  3. Article
  4. Article
  5. Incidence, risk factors and clinical course of pyogenic spondylodiscitis patients with pulmonary embolism.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2022
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Daniel DubinskiDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany. danieldubinski@gmail.com.ORCID http://orcid.org/0000-0001-5568-8429
Fee KeilInstitute of Neuroradiology, Goethe University, Frankfurt, Germany.
Sae-Yeon WonDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
Bedjan BehmaneshDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
Kolja JahnkeDepartment of Neurology, University Hospital, Goethe University, Frankfurt, Germany.
Volker SeifertDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
Christof GeisenInstitute for Transfusion Medicine and Immunohematology, Goethe University, Frankfurt, Germany.
Juergen KonczallaDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
Christian SenftDepartment of Neurosurgery, University Hospital, Goethe University, Frankfurt, Germany.
Goethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary embolism (PE) due to deep vein thrombosis is a complication with severe morbidity and mortality rates. Neurocritical care patients constitute an inhomogeneous cohort with often strict contraindications to conventional embolism treatment. The aim of the present study is to identify risk factors for pulmonary embolism for intensified risk stratification in this demanding cohort. In this retrospective analysis, 387 neurocritical care patients received computed tomography for clinical suspicion of PE (304 neurosurgical and 83 neurological patients). Analysed parameters included age, gender, disease pattern, the presence of deep vein thrombosis, resuscitation, in-hospital mortality, present anticoagulation, coronary artery disease, diabetes mellitus, smoking status, hypertension and ABO blood type. Computed tomography confirmed 165 cases of pulmonary embolism among 387 patients with clinical suspicion of pulmonary embolism (42%). Younger age (p < 0.0001), female gender (p < 0.006), neurooncological disease (p < 0.002), non-O blood type (p < 0.002) and the absence of Marcumar therapy (p < 0.003) were identified as significant risk factors for pulmonary embolism. On the basis of the identified risk factors, the AMBOS score system is introduced. Neurocritical care patients with high AMBOS score are at elevated risk for PE and should therefore be put under intensified monitoring for cardiovascular events in neurocritical care units.

Indexed as

Severity of Illness IndexAdultAgedAged, 80 and overCohort StudiesCritical CareFemaleGermanyHospital MortalityHumansMaleMiddle AgedPulmonary EmbolismRetrospective StudiesRisk FactorsTomography, X-Ray ComputedBlood groupDeep vein thrombosisNeurocritical careRisk factorThromboembolism

Identifiers

PMID32399727
PMCPMC8035103
OpenAlexW3025662151

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.