ArticleLasers in medical science2021
Laser enhancement of cancer cell destruction by photothermal therapy conjugated glutathione (GSH)-coated small-sized gold nanoparticles.
Article in Lasers in medical science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 20 citations in OpenAlex.
- Multifunctional gold nanoparticles: bridging detection, diagnosis, and targeted therapy in cancer.Molecular cancer · 2025Review
- Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Clinical insights into nanomedicine and biosafety: advanced therapeutic approaches for common urological cancers.Frontiers in oncology · 2024Review
- Photothermal treatment of glioblastoma cells based on plasmonic nanoparticles.Lasers in medical science · 2023Article
- Nanoparticle Systems for Cancer Phototherapy: An Overview.Nanomaterials (Basel, Switzerland) · 2021Review
- Multifunctional CuBiSFrontiers in bioengineering and biotechnology · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The current study presents the employment of glutathione (GSH)-modified small-sized gold nanoparticles (AuNPs) ~ 3 nm in photothermal therapy (PTT), to evaluate the targeting and the toxic effect of cancer rather than normal cells. GSH is pH-sensitive surfaces that exhibit a fast response to the variation in pH conditions between normal (~ 7.4) and cancer cells (6-6.5). Results showed a considerable toxic impact via GSH-AuNP accumulation in cancer cells by both green and NIR laser irradiation. A proportional relation of cellular death to AuNP concentration, exposure time, and light-to-heat conversion efficiency has been demonstrated. The small-sized GSH-AuNPs represent promising agents for developing the safety issues of photothermal cancer treatment by the selective targeting of cancer rather than normal cells, reducing the NP toxicity by their size overlapping with the renal clearance barrier of kidney filtration (~ 5.5 nm), and promoting the photothermal performance in the NIR region, in which light penetration into deep cancer regions is more interested.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.