Evidence map›Paper›PMID 32399686›Full record

Observational studyPediatric radiology2020

Third-trimester in utero fetal brain diffusion tensor imaging fiber tractography: a prospective longitudinal characterization of normal white matter tract development.

Jeffrey D Hooker, Majid A Khan, Amy B Farkas, Seth T Lirette, David A Joyner, David P Gordy, Judd M Storrs, Manohar S Roda, James A Bofill, Andrew D Smith and 1 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Development of the Fetal Brain Corticocortical Structural Network during the Second-to-Third Trimester Based on Diffusion MRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  5. Article
  6. Development of the Ontogenetic Self-Regulation Clock.International journal of molecular sciences · 2022
    Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jeffrey D HookerDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA. jeffreydavidhooker@gmail.com.ORCID 0000-0003-4299-6152
Majid A KhanDepartment of Radiology, Johns Hopkins Hospital, Baltimore, MD, USA.
Amy B FarkasDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
Seth T LiretteDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
David A JoynerDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
David P GordyDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
Judd M StorrsDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
Manohar S RodaDepartment of Radiology, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS, 39216, USA.
James A BofillDepartment of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA.
Andrew D SmithDepartment of Radiology, University of Alabama at Birmingham, Birmingham, AL, USA.
Judy R JamesDepartment of Radiology and Imaging Sciences, Indiana University Health University Hospital, Indianapolis, IN, USA.

Funding

Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI COMPRETTA, CAROLINE E. · 2016 to 2025
$38.2M
NIGMS NIH HHS U54 GM115428
6 · The paper itself

Abstract

backgroundWhite matter is responsible for inter-neuronal connections throughout the brain that are a driving force in cognitive development. Diffusion tensor imaging (DTI) fiber tractography has been used to evaluate white matter development in the fetal brain; however, longitudinal studies of DTI fiber tractography to assess white matter development in the third trimester are lacking.

objectiveTo characterize in utero longitudinal changes in the fetal brain DTI fiber tracts of normal third-trimester fetuses. MATERIALS AND

methodsFor this single-center prospective longitudinal observational pilot study, we recruited 28 pregnant females with normal third-trimester pregnancies who had routine prenatal ultrasound. MRI of the in utero fetal brain was performed with a Siemens 1.5-tesla (T) Espree scanner at 31 weeks, 33 weeks and 36 weeks of gestation, with 14 DTI tractography parameters quantified in 7 brain regions using DTI-studio version 2.4 (Johns Hopkins University, Baltimore, MD; n=98 measurements). We used multilevel mixed models to examine the relationship between longitudinal changes in DTI measurements and between 98 DTI measurements at 31 weeks and 4 routine fetal brain anatomical biometrics (n=392 assessments).

resultsWe observed statistically significant decreases in radial diffusivity and apparent diffusion coefficient in 13 of 14 brain regions from 31 weeks to 36 weeks of gestation (P<0.001 for all regions except the genu of the corpus callosum). Significant decreases in radial diffusivity from weeks 33 to 36 and weeks 31 to 36 were seen in the corticospinal tracts, centrum semiovale, posterior limb of the internal capsule, and crus cerebri (P<0.001 for all). When considering all possible combinations of DTI fiber tract measurements and the routine morphological fetal brain biometrics, only 6% (24/392) had a significant association (P<0.05), indicating relative independence of the DTI fiber tract measurements from anatomical biometrics.

conclusionIn utero longitudinal changes in fetal brain DTI fiber tractography are quantifiable in normal third-trimester fetuses and are largely independent of morphological brain changes.

Indexed as

AdultDiffusion Tensor ImagingFemaleHumansLongitudinal StudiesPilot ProjectsPregnancyPregnancy Trimester, ThirdProspective StudiesWhite MatterBrainDiffusion tensor imagingFetusMagnetic resonance imagingNormal measurementsThird trimesterTractography

Identifiers

PMID32399686

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.